Human Matrix Metalloproteinase 15

Reference Number TO 03-00009

The Challenge

The matrix metalloproteinases (MMPs) comprise a group of at least 20 proteolytic enzymes that play an essential role in tissue remodelling. Each MMP binds a bivalent metal-ion and hydrolyses proteins of extra-cellular matrix. MMPs influence physiological processes in human bodies, such as wound healing and scarring. Subsequently, several pathological processes of different diseases such as metastasis of tumours  or arthritis are strongly affected by MMPs. Different control mechanisms on molecular and cellular level are known.
Due to their important role in human body, MMPs are important targets for the development of new diagnostics and therapeutics.

The Technology
The cDNA and protein sequence of human matrix metalloproteinase 15 is disclosed. The cDNA and protein can be used to examine and evaluate its function and the reactions regulated in human body.

Commercial Opportunity
There are several commercial uses for the disclosed matrix metalloproteinase:
- screening tool, e.g. on microarrays
- measurement of expression rates
- measurement of degradation of proteins
- screening of protease-effectors
- diagnostic measurement of matrix metalloproteinases 
- screening and evaluation of MMP inhibitors and their actions

Patent situation
A German and two US Patents were granted, claiming matrix metalloproteinase 14 and matrix metalloproteinase 15 (DE 44 38 838, US 6,114,159, US 6,399,348). A European Patent was granted in 2001, claiming matrix metalloproteinase 15 (EP 0 750 672).

Further Reading
Will H., Hinzmann B. “cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment” Eur. J Biochem. 1995 Aug 1;231(3):602-8.

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Kontakt:

Karen Uhlmann, Ph.D.
Technology Manager
Ascenion GmbH

T: +49 (0)30 9406 2301
F: +49 (0)30 9406 2302
uhlmann(at)ascenion.de