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Spinning Innovation

Certus Pharmaceuticals – new shuttles for chemotherapie

 
Certus Pharmaceuticals key facts

Technology:
Novel drug delivery approaches based on charge-neutral nanoparticels or embolizing agents

Advantage:
Extends the therapeutic window of conventional drugs by increasing the drug accumulation in tumor, increasing their exposure time to the drugs (> 25 fold) and decreasing toxic side effects.
 
Products:
Two candidates under development:
- a compound for the treatment of liver cancer
- a nanoparticle containing the chemotherapeutic agent paclitaxel

Development Status:
Preclinical, first-in-man data from a physician-sponsored trial

Originating Institution: Max Delbrück Center for Molecular Medicine, Berlin-Buch (MDC)

Certus is the first spin-out from one of Ascenion’s partner institutes to build its new venture in the US. Based in South San Francisco, California, co-founder and CSO Peter Scherrer has already attracted a group of experienced industry managers and drug discovery experts to the Certus Board of Directors. The team has just initiated Certus’ first financing round. “They are perfectly set to exploit the potential of the innovative drug-delivery technologies that were developed at the MDC,” Christian Stein, CEO of Ascenion comments.

 “We have carefully evaluated different routes of commercialization – on both sides of the Atlantic – and identified Certus as an ideal licensing partner.” The potential of the technologies is enormous, medically as well as commercially. “Based on our technology platforms, we hope not only to improve the safety and efficacy of chemotherapy for a large group of cancer patients but also to provide the first effective treatment option for patients suffering from liver cancer,” Scherrer comments.

Protectimmun - stable dust against hay fever and asthma

Protectimmun key facts

Approach:
Using components of stable dust for the prevention of hay fever and allergic asthma

Advantage:
Potential to safely induce long-term immunity to hay fever and allergic asthma

Products:
Preventive nose spray

Development Status:
Preclinical

Originating Institutions:
Research Center Borstel (FZB), Ruhr-University Bochum

Protectimmun is the second spin-off from Ascenion’s partner institutions in the Leibniz Association that Ascenion has helped get off the ground – just two years after the partners started to collaborate with regards to IP protection and commercialization. Protectimmun’s business concept is based on international studies demonstrating that children who regularly spent time in farm stables during their first year of life were virtually immune to hay fever and allergic asthma later in life. In light of this, scientists at the FZB and the Ruhr-University Bochum have developed procedures for  extracting soluble components from stable dust that can be administered in aerosol form, e.g. as a nose spray. Preclinical testing is ongoing and the team is about to initiate its first financing round. Furthermore, Protectimmun has recently identified the active components in stable dust and has expanded its patent position appropriately. “This further endorses our position in negotiating with investors,” Marion Kauth, CEO of Protectimmun, comments. “And it is an important milestone on our way towards a safe and easily applicable medication that could effectively protect children from developing allergic respiratory diseases.” With its approach, Protectimmun addresses an urgent medical need and an attractive market, since more and more children are suffering from these kinds of allergies.

Meet us at the forthcoming events:

2008-11-17 to 2008-11-19
BIO-Europe, Mannheim / Heidelberg, Germany

2008-11-28 to 2008-11-29
Doktorandencamp 2008, Headquarters of the Fraunhofer-Gesellschaft and Munich Business School, Munich, Germany

2009-02-10
Seminar on "IP Asset Management - from theory to practice",
Ludwig-Maximilian University, Munich, Germany


2009-03-04 to 2009-03-06
BioTech Networkshop, Tutzing, Germany

2009-05-08
BioVaria, Munich, Germany


News in brief:


In dialogue with the Wellcome Trust and HTGF
Ascenion invited representatives of the Wellcome Trust and the High-Tech Gründerfonds (HTGF) to learn about some of the most attractive projects from its portfolio.
.more


“Biting” Antibodies against cancer
Micromet’s BiTE® antibodies are designed to activate T cells, the body’s most potent “killer” cells, specifically against cancer cells.more


PARF: One idea – many applications
 
“PARF” (peptide associated with rheumatic fever) is a peptide that is present on certain pathogenic bacteria of the streptococcal family. It was discovered and described by HZI researchersmore


Improving technology transfer in national genome research
With the expiry of the national genome research network (NGFN) at the end of last year, the Federal Ministry of Education and Research restructured its support programme for medical genome research in Germany.more


New employee to support the KompetenzCenter
In May this year, Anja Kroke joined Ascenion to support the activities of the KompetenzCenter.more


Contact us:

Munich:
T +49 89 318814-0
info(at)ascenion.de

Berlin:
T +49 30 9406 230 -1/-4
berlin(at)ascenion.de

Braunschweig:
T +49 531 6181 2090
braunschweig(at)ascenion.de

Hamburg:
T +49 40 22611 278
habeck(at)ascenion.de

Hanover:
T +49 511 5328 921
cordes(at)ascenion.de

Neuherberg:
T +49 89 3187 2850
scheek(at)ascenion.de

Ascenion GmbH, www.ascenion.de