Novel Antimicrobial Peptides

Referenznummer TO 01-00795

Challenge

In the last two decades the prevalence of antibiotic-resistant bacteria has increased dramatically. Multi-drug-resistant strains have emerged in many species that cause disease in humans. Currently there are only insufficient treatments available for infections caused by many of the antibiotic-resistant bac-teria. Furthermore the resistance to commonly used antibiotics is steadily increasing. In consideration of this fact alternative methods to combat antibiotic resistant bacteria are urgently needed. Therefore the development of novel antibiotics less prone to resistance as well as resistance formation is critical and constitutes a medical need.


	Proposed mechanism of action of antimicrobial peptides

Technology

The present invention relates to a group of novel polypeptides derived from plants that were further optimized and show efficient antibiotic activity towards a variety of plant pathogens as well as human pathogens. The peptides comprise an amphi-pathic helical structure which allow them to incorporate into bacterial membranes. They are supposed to target the prokaryotic cytoplasmic membrane by membrane perforation resulting in the efflux of prokaryotic cytoplasma.Another important feature of the present invention is the low haemolytic activity of the peptides making the compounds suitable for antibiotic use.

Commercial Opportunity

Antimicrobial peptides belong to a very old group of natural compounds that don’t seem to evoke pronounced resistance formation. They might present a new generation of secure antibiotics.

In-licensing or collaboration partnership for the development

Patent Situation

Four EP patent applications are pending.

Further Reading

Hanock & Sahl, Nat. Biotech. 2006, Vol. 24, p. 1551