Antiobiotic salts suitable for implant coating

Reference Number: TO 10-00028

Challenge
Orthopaedic implants help millions of people to stay active. These medical devices though are prone to infection, forcing patients back to surgery for repair or replacement. Post-surgical implant infection often is aggressive and remains the primary cause of implant failure. Bacterial contamination during surgery and subsequent adhesion of opportunistic microorganisms onto biomaterial surface provoke the implant infection. However, a particular antibiotic coating of the implant could discourage bacterial growth. 

Technology
The invention describes antibiotic maduraphthalazin salts that show a low solubility in water and a delayed release of the active substance. The innovative maduraphthalazin salts are characterized by the fact that they consist of an anionic component, which is formed by at least one representative of the group of carboxyalkylated or carboxyarylated highly active watersoluble maduraphthalazins and of a cationic antibiotic component, like gentamicin, kanamycin, amikacin, clindamicin, neomycin, streptomycin, vancomycin, tetracycline, doxicyclin, oxytetracyclin or rolitetracyclin. In human and veterinary medicine, the antibiotic maduraphthalazin salts that show a low solubility in water can be used in permanent or temporary implants and as an element of implant coatings in the fight agains

Commercial Opportunity
There is an urgent demand for antibiotic coatings to enhance the residence time of implants in the body and to reduce the risk of inflammation.
Advantages of the offered novel compounds are
- combination of known highly active antibiotics against a broad 
   range of pathogens
- slow release of active compounds 

A cooperation agreement with option for an exclusive or non-exclusive license or a license agreement (exclusive or non-exclusive) are possible deals.

Patent Situation
An international application has been filed in 2007.

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Contact:

Sabina Heim, Ph.D.
Technology Manager
Ascenion GmbH

T: +49 (0)531-6181-2090
F: +49 (0)531-6181-2098
heim@ascenion.de