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Magnesium alloys with adjustable corrosion ratesReferenznummer TO 15-00042
Challenge
Magnesium based implants provide clear advantages for patients with bone fractures or defects due to a good biocompatibility and a high primary stability. Furthermore, degradable magnesium alloys have been introduced into orthopaedic and trauma surgery to avoid the need for a second operation for implant removal. However, hazardous amounts of hydrogen may accumulate in subcutaneous gas bubbles when the magnesium implants degrade too quickly. In a search for degradable bone implants with high primary stability and controllable degradation rates, new categories of magnesium alloys had to be developed.
Technology The technology relates to the manufacture and use of special magnesium alloys, whose degree of corrosion can be adjusted up to full corrosion resistance. Various magnesium based alloys may be used for halide-modification in the course of standard alloying processes. Additionally, the modified substances can be applied to prefabricated workpiece surfaces by spraying or sintering techniques. Thanks to the highly flexible material properties the new alloys can be utilized in a broad array of applications like absorbable or permanent medical implants, prostheses and medical instruments.
The technology is available for in-licensing. Cooperation for further development is also possible.
A sample magnesium alloy has been manufactured by diffusion or melt alloying and subsequently tested in an animal study.
European patent application EP 1458426 is about to be granted.
Witte et al. (2005) In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials (26) 3557–3563.
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Contact: Ralf Cordes, Ph.D. T: +49 (0)511 532 8921 |
