lncRNAs in therapy and diagnosis of disease related angiogenesis
Angiogenesis is an essential mechanism which is often closely related to physiological changes during pathogenesis. A prominent example is the transition from a benign to a malignant tumor which is accompanied by pro-angiogenic activities. Therefore, it is of utmost importance to elucidate the molecular mechanisms of pathological angiogenesis. Recent studies could indicate the involvement of long non-coding RNAs (lncRNAs) in angiogenic signaling. LncRNAs are extracellular nucleic acids representing a novel class of regulatory molecules. Latest research identified lncRNAs as promising tools for the specific diagnosis and therapy of cancer or cardiovascular diseases. Accordingly, lncRNAs have great potential to form a novel class of diagnostic and therapeutic tools in disease related angiogenesis.
The technology relates to a recently discovered subset of lncRNAs which are significantly dysregulated during hypoxia. In particular, in-depth analysis could reveal a specific lncRNA with a remarkable pro-angiogenetic function in endothelial cells. Over-expression resulted in an enhanced transcription of various angiogenesis related genes. Due to a dynamic regulation of the transcriptome in pathological processes, the pro-angiogenic lncRNA emerges as a new and specific tool for diagnosis and therapy of pathological conditions, e.g. in cardiovascular diseases. Thus, the herewith presented lncRNA enables the timely treatment of disease onset and renders possible a therapy of the patient at an early stage.
In-licensing or collaboration for further development is possible.
In vitro and in vivo studies for the identification and evaluation of angiogenesis-related lncRNAs were successfully performed. Further validation is in progress.
Patents have been granted in Europe (EP 3134527B1) and USA (US 10,221,417B2) with priority of 2014.
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