Mice homozygous for the Cd5tm1Cgn targeted mutation are viable and apparently healthy. Both T and B cells in homozygous mutant mice lack surface CD5. Mice show normal immune responses to both T cell-dependent and -independent antigens.
Immunology and Inflammation Research:
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.