Mice homozygous for the Igh-5tm1Cgn targeted mutation are viable and fertile. Homozygous mutant mice show a delay in affinity maturation although they are able to generate high affinity B cell memory. Heterozygous mice show a disproportionate percentage of B cells expressing the wildtype IgH allele. Also known as IgD.
Immunology and Inflammation Research:
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.