Mice homozygous for the targeted mutation are viable and fertile when housed under SPF conditions. At 3 months of age mutant mice exhibit severe intestinal lesions, increased granulocyte counts and elevated serum amyloid A levels. There is a 67% prevalence of colorectal adenocarcinoma. This mutant mouse strain represents a model that may be useful in studies related to inflammatory bowel disease.
Cancer Research:Growth Factors/Receptors/Cytokines
Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects
Immunology Inflammation Research:
and Autoimmunity Growth Factors/Receptors/Cytokines Immunodeficiency, Inflammation (Inflammatory bowel disease)
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.