This strain expresses Cre recombinase from the endogenous Lyzs locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.
Genetics Research (Tissue/Cell Markers: Cre-lox system), Lyzstm1(cre)Ifo related, Developmental Biology Research, Internal/Organ Defects (Lymphoid Tissue Defects), Lymphoid Tissue Defects (hematopoietic defects)
Cancer Research (Leukemia), Cre-lox-System, Genetics Research (Mutagenesis and Transgenesis: Cre-lox system), Hematological Research, Immunology and Inflammation Research (Macrophage Deficiency), Immunology and Inflammation Research (genes regulating susceptibility to infectious disease and endotoxin)
Hematopoietic Defects, Immunological Defects, Neutrophil Defects
Immunology and Inflammation Research:
Autoimmunity (experimentally induced rheumatoid arthritis)
CD Antigens, Antigen Receptors, and Histocompatibility Markers (genes regulating susceptibility to infectious disease and endotoxin), Growth Factors/Receptors/Cytokines, Immunodeficiency (Neutrophil Defects)
Inflammation (Inflammatory bowel disease), Inflammation (Neutrophil function)
Lymphoid Tissue Defects (hematopoietic development), Lymphoid Tissue Defects (myeloid hyperplasia)
Gastrointestinal Defects (colitis), Lymphoid Tissue Defects
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.