Mice homozygous for the Igl-5tm1Cgn mutation are viable and fertile. Homozygotes show a block in B cell development in bone marrow at the pre-B cell stage; however, blockage is leaky and a low percentage of B cells do get to the peripheral immune system.
Immunology and Inflammation Research:
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.