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C.129P2(B6)-Il10tm1Cgn/J

Jackson Stock Number: 004333

Abstract

Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under specific pathogen-free (SPF) conditions. The phenotype of Il10-deficient mice is strongly influenced by the genetic background. At 3 months of age, Il10tm1Cgn homozygous mutant mice on a BALB/c background exhibit severe intestinal lesions, increased granulocyte counts, and elevated serum amyloid A levels. There is a 29% prevalence of colorectal adenocarcinoma. This mutant mouse strain represents a model that may be useful in studies related to inflammatory bowel disease.

Cancer Research:
Increased Tumor Incidence (Adenomas: intestinal adenomas)

Cell Biology Research:
Genes Regulating Growth and Proliferation

Immunology and Inflammation Research:
Lymphoid Tissue Defects (myeloid hyperplasia)

Internal/Organ Research:
Gastrointestinal Defects (colitis)
Il10tm1Cgn related

Cancer Research:
Growth Factors/Receptors/Cytokines

Hematological Research:
Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects

Immunology and Inflammation Research:
Autoimmunity
Growth Factors/Receptors/Cytokines
Immunodeficiency
Inflammation (Inflammatory bowel disease)

Further Reading & Data Sheet

See information from The Jackson Laboratory


This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.