Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under SPF conditions. Under conventional housing conditions homozygous mutant mice are small in size, anemic, and have chronic enterocolitis. It should be noted that the phenotype of cecocolitis in this strain requires an interaction with an as yet undefined component of the enteric flora. Helicobacters do not appear to be the environmental triggers. Intestinal problems are far less severe (local inflammation of the proximal colon) in a pathogen-free environment. Lymphoctye development and antibody responses are normal in homozygous mutant mice.
Anemia, Iron Deficiency and Transport Defects (hemolytic)
Immunology and Inflammation Research:
Inflammation (Inflammatory bowel disease)
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.