Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under SPF conditions. Under conventional housing conditions homozygous mutant mice are small in size, anemic, and have chronic enterocolitis. It should be noted that the phenotype of cecocolitis in this strain requires an interaction with an as yet undefined component of the enteric flora. Helicobacters do not appear to be the environmental triggers. Intestinal problems are far less severe (local inflammation of the proximal colon) in a pathogen-free environment. Lymphocyte development and antibody responses are normal in homozygous mutant mice. For a more detailed description please refer to the JAX Notes Fall 1997 article.
Important Health Status Considerations:
Our colony of these IL10 deficient mice is maintained in isolators under conditions which preserve the presence of potentially strain-unique enteric flora required for the development of IBD. This includes the presence of Helicobacter spp., which is a marker for the presence of the additional microbiota required for colitis development.
Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects
Immunology and Inflammation Research:
Autoimmunity, Growth Factors/Receptors/Cytokines, Immunodeficiency
Inflammation (Inflammatory bowel disease)
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.