Mice homozygous for the Itgb7tm1Cgn targeted mutation have a marked hypoplasia of the gut-associated lymphoid tissue (GALT). This deficit is apparently due to the failure of Itgb7-deficient lymphocytes to arrest and adhere in the GALT.
Cell Biology Research:
Defects in Cell Adhesion Molecules
Immunology and Inflammation Research:
Lymphoid Tissue Defects
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.