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NOD.129P2(B6)-Il4tm1Cgn/DvsJ

Jackson Stock Number: 004222

Abstract

Complete Freund's adjuvant (CFA) induced suppression of diabetes in NOD mice has been associated with a shift to Th2 cytokine production. NOD mice deficient in IL4 were created to investigate the role of IL4 in this shift. Mice homozygous for the Il4tm1Cgn targeted mutation are viable and fertile. T and B cell development is normal but IgG1and IgE levels and the ability of homozygous mutant mice to produce Th2-derived cytokines are significantly reduced. IL4 deficient NOD mice develop IDDM with the same incidence as standard NOD/Lt controls, and there is no change between IL4 deficient and wildtype NOD in disease protection conferred by treatment of bacillus Calmette-Guerin vaccine (BCG) or CFA. Both IL4 deficient and wildtype NOD mice are significantly protected from insulitis by treatment of CFA but not by treatment of BCG. (Serreze et al 2001)

Diabetes and Obesity Research:
Impaired Wound Healing
Islet Transplantation Studies
Type I Diabetes (IDDM) (Congenics with mutations affecting cytokine production by autoreactive T cells)
Type I Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells)
Type I Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence)

Hematological Research:
Immunological Defects

Immunology and Inflammation Research:
Immunodeficiency (specific T cell deficiency), Immunodeficiency Associated with Other Defects, Inflammation, Lymphoid Tissue Defects, Vaccine Development

Internal/Organ Research:
Wound Healing

Research Tools:
Cancer Research (T cell deficiency; xenograft/transplant host)
Immunology and Inflammation Research (genes regulating susceptibility to infectious disease and endotoxin; production of T cell lines and hybridomas; specific T cell deficiency), Toxicology Research (B & T cell deficiency) (xenograft transplant host), Il4tm1Cgn related, Cancer Research, Growth Factors/Receptors/Cytokines

Further Reading & Data Sheet

See information from The Jackson Laboratory


This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.