This strain was derived from an initial cross between mice of strains NOD/Lt and C57BL/6-Itgb7tm1Cgn (Stock No. 002965), followed by 10 backcrosses (to N11) to NOD/Lt of progeny selected for heterozygosity for the targeted allele. Heterozygous offspring of the final backcross were intercrossed to initiate a line homozygous for Itgb7tm1Cgn, and the strain was then maintained by sibling inbreeding. Statistically, this strain's genome is approximately 99.95% of NOD/Lt origin. (NOD.B6-Itgb7tm1Cgn/Lt (Stock No. 004310) was generated from an intercross between heterozygous mice at backcross generation N6 of the same line.)
Cell Biology Research:
Defects in Cell Adhesion Molecules
Immunology and Inflammation Research:
Lymphoid Tissue Defects
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.