Transgenic mice carrying the Igh-6tm1Cgn allele are viable, fertile, and normal in size and restores the B220+ B-cells. The number of B-cells is reduced and the ratio of CD4 to CD8 is normal. Although only a fraction of the transgenic mice have an increased amount of insulitis, it is significantly more severe, especially in males. No diabetes was observed in NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6 )2Mjsk/Fsw mice by 50 weeks of age.
This model serves as a control for the membrane bound, non-secreted, NODCaj.Cg-Igh-6tm1Cgn Tg(Igh-VB1-8/Igh-6m)1Mjsk/FswJ (stock# 5306).
Diabetes and Obesity Research:
Type 1 Diabetes (IDDM), Type 1 Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Immunocompetence), Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)
Immunology and Inflammation Research:
Autoimmunity (B cell deficiency), Autoimmunity (Type 1 Diabetes), Immunodeficiency (B cell defects)
Immunology and Inflammation Research, Immunodeficiency (B cell deficiency)
Cancer Research (B cell deficiency), Immunology and Inflammation Research (B cell deficiency)
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.