Mice homozygous for the Il10 and Il4 targeted mutations are viable and fertile when housed under SPF conditions. NOD/Lt mice deficient for both of these genes develop type 1 diabetes at a rate equivalent to the parental strain. The Il10 tm1Cgn mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.
Diabetes and Obesity Research:
Type I Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations, ffecting Cytokine Production by Autoreactive T Cells), Il10tm1Cgn related
Growth Factors/Receptors/Cytokines, Growth Factors/Receptors/Cytokines
Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects
Immunology and Inflammation Research:
Autoimmunity, Growth Factors/Receptors/Cytokines, Immunodeficiency, Inflammation (Inflammatory bowel disease), Il4tm1Cgn related, Growth Factors/Receptors/Cytokines
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.