Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under SPF conditions. This mutant develops type 1 diabetes at the same rate as the NOD/Lt parental strain. The Il10 tm1Cgn mutation also renders this NOD/Lt stock susceptible to colitis (although not as severe as other strains of Il10 deficient mice) when maintained under standard housing conditions.
Diabetes and Obesity Research:Impaired Wound Healing, Islet Transplantation Studies, Type I Diabetes (IDDM) (Congenics with mutations affecting cytokine production by autoreactive T cells), Type I Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells), Type I Diabetes (IDDM) Analysis Strains (NOD Congenics with Mutations, ffecting Immunocompetence)
Immunology and Inflammation Research:
Immunodeficiency Associated with Other Defects, Lymphoid Tissue Defects, Vaccine Development
Cancer Research (T cell deficiency), Cancer Research (xenograft/transplant host)
Immunology and Inflammation Research (genes regulating susceptibility to infectious disease and endotoxin, production of T cell lines and hybridomas, specific T cell deficiency), Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects, Immunology and Inflammation Research, Autoimmunity, Growth Factors/Receptors/Cytokines, Immunodeficiency, Inflammation (Inflammatory bowel disease)
Toxicology Research (B & T cell deficiency) (xenograft transplant host), Il10tm1Cgn related, Gastrointestinal Defects (colitis), Wound Healing
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.