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STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J

Jackson Stock Number: 004192

Abstract

These mice are homozygous for four different induced mutations. The cumulative result of these mutations is a mouse model in which hypercholesterolemia can be reversed. By themselves, the combined presence of the Ldlrtm1Sgy and Apobtm1Sgy targeted alleles results in mice with a high susceptibility to atherosclerosis and total plasma cholesterol levels of approximately 300 mg/dl. A functional microsomal triglyceride transfer protein gene (Mttp) is essential for establishing a hypercholesterolemic condition. By flanking the Mttp gene with loxP sites and including a Mx1-Cre transgene, it is possible to reduce total plasma cholesterol levels from 300 mg/dl to 30 mg/dl upon induction of the Cre recombinase by administering interferon alpha, interferon beta, or synthetic double-stranded RNA. This unique model is useful in research related to the mechanisms and events of atherosclerotic reversal. Mice homozygous for the targeted alleles are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.re related

Research Tools:
Cre-lox-System, Genetics Research (Mutagenesis and Transgenesis: Cre-lox system), Apobtm2Sgy related, Atherosclerosis, Hypocholesterolemia, Hypotriglyceridemia, Developmental Biology Research, Neural Tube Defects, Mouse/Human Gene Homologs, hypobetalipoproteinemia, familial, Neurobiology Research, Neural Tube Defects, Ldlrtm1Her related, Cardiovascular Research, Atherosclerosis, Hypercholesterolemia

Metabolism Research:
Lipid Metabolism, Mouse/Human Gene Homologs, hypercholesterolemia, familial
Mttptm1Sgy related

Metabolism Research:
Lipid Metabolism

Further Reading & Data Sheet

See information from The Jackson Laboratory


This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.