These transgenic mice carry the Cre recombinase gene under the control of the rat nestin promoter. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre, generating a proportion of mosaic animals. All adult organs, including germ-line cells, may be affected. The balancer 2 line of transgenic mice show greater variability and instability in their generation of mosaics than the balancer 1 line (stock number 002858 - STOCK TgN(balancer1)2Cgn). This variability of the balancer 2 line can be of particular benefit if the gene of interest is vital and mosaic individuals are used to bypass lethality.
Developmental Biology Research (Cre-lox system), Reproductive Biology Research (Cre-lox system), cre related
Cre-lox-System, Genetics Research (Mutagenesis and Transgenesis: Cre-lox system)
Further Reading & Data Sheet
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.