UV-Fit – increasing metabolic fitness and reducing body weight without fasting

Technology Description

The inventors demonstrated in an in vivo animal model that short-term exposure to UV-B radiation in the range of 305-315 nm leads to metabolic remodeling, which is identical to effects of calorie restriction. The changes were dose dependent and can be monitored by a series of physiological markers such as lipid catabolism. This allows personalized treatment by applying a fine-tuned dose calibration procedure, which is based on the patient´s skin type and well-established blood tests for specific markers, facilitating the adjustment of the method for each individual patient on a “maximal benefit – no harm” basis. Phototherapy with UV-B-radiation is a widely used and safe treatment for skin diseases, such as psoriasis, acne vulgaris and eczema, which can be carried out in a clinic or even at home by means of already established UV-B home systems. Beside the positive effects on skin diseases, studies have already proven the benefits of UV-B-radiation for the systemic homeostasis and the synthesis of vitamin D. The invention demonstrates that, due to its newly discovered metabolic remodeling properties, specially calibrated narrow-band (305-315 nm) UV-B phototherapy can also be used for the treatment of diseases such as metabolic syndrome, obesity, fatty liver, as well as for fitness purposes and cosmetic weight reduction without fasting.