C.129P2(B6)-Il10tm1Cgn/J
Keywords
Animal Model C.129P2(B6)-Il10tm1Cgn/J
Abstract
Mice homozygous for the Il10tm1Cgn targeted mutation are viable and fertile when housed under specific pathogen-free (SPF) conditions. The phenotype of Il10-deficient mice is strongly influenced by the genetic background. At 3 months of age, Il10tm1Cgn homozygous mutant mice on a BALB/c background exhibit severe intestinal lesions, increased granulocyte counts, and elevated serum amyloid A levels. There is a 29% prevalence of colorectal adenocarcinoma. This mutant mouse strain represents a model that may be useful in studies related to inflammatory bowel disease.
Cancer Research:
Increased Tumor Incidence (Adenomas: intestinal adenomas)
Cell Biology Research:
Genes Regulating Growth and Proliferation
Immunology and Inflammation Research:
Lymphoid Tissue Defects (myeloid hyperplasia)
Internal/Organ Research:
Gastrointestinal Defects (colitis)
Il10tm1Cgn related
Cancer Research:
Growth Factors/Receptors/Cytokines
Hematological Research:
Anemia, Iron Deficiency and Transport Defects (hemolytic), Immunological Defects
Immunology and Inflammation Research:
Autoimmunity
Growth Factors/Receptors/Cytokines
Immunodeficiency
Inflammation (Inflammatory bowel disease)
Further Reading & Data Sheet
See information from The Jackson Laboratory
This animal model is bred and managed by The Jackson Laboratory and marketed for commercial use by Ascenion.