Prokaryotic expression systems are widely used for the production of recombinant proteins, but often encounter problems to obtain sufficient yields of the functionally active gene products. Most challenging is the formation of inclusion bodies, incorrect folding of the expressed protein, protein toxicity for the producer cells and protein…
Challenge Genetically modified animals are essential research tools in modern neuroscience, since they allow researchers to study the role of specific genes in pathological processes leading to neurodegenerative diseases. The myelin-associated glycoprotein (MAG) is a transmembrane glycoprotein localized in the myelin sheath membranes of periaxonal…
Challenge Genetically modified animals are essential research tools in modern neuroscience, since they allow researchers to study the role of specific genes in pathological processes leading to neurodegenerative diseases. Tenascin-R (TNR) is an extracellular matrix glycoprotein expressed predominantly in the central nervous system and localizes to…
Challenge Genetically modified animals are essential research tools in modern neuroscience, since they allow researchers to study the role of specific genes in pathological processes leading to neurodegenerative diseases. The close homologue of L1 (CHL1), a member of the L1 family of cell adhesion molecules, is abundantly expressed by neurons and…
Voxel models constructed from image data of living persons offer an anatomically realistic representation of the human body and therefore an improvement to MIRD-type models. Computational models of the human body can be applied to all kinds of dose calculations, e.g. the ICRP is using voxel models for future dose calculations. The availability of…
H2BUb1 (histone2B, ubiquintylated)
The novel technology allows for a development of electric biosensors and is based on the application of surface-near electrostatic forces above structured doped semiconductors for the immobilization, transport, and modification of electrically polarizable biomaterials. Static and dynamic electric forces can be…
LncRNA LIPCAR predicts disease progression in heart failure and myocardial infarction patients (TO 15-00366)
15-00366
Levels of LIPCAR in patients with future cardiovascular death vs patients without cardiovascular death (Kumarswamy et al.)
The invention introduces mitochondrial long non-coding RNA (lncRNA) LIPCAR as a predictive biomarker…
Along with the growing number of patients with a weak or suppressed immune system – e.g. due to aging populations in western societies, cancer or HIV - comes a growing number of opportunistic fungal infections. On the other hand, only five new products suitable to combat these infections have been granted market approval by the FDA during the last…
Age-correlated dementia causes growing social and economic problems in industrial nations. Among different forms of dementia, Alzheimer’s disease (AD) is the most common. Experimental evidence suggests the pathology of the central nervous system as well as the patients’ cognitive decline be a result of vascular lesions in AD patients’ brains. In…
Cluster A mAbs CALCA 3C5, 2F3 and 4H6 react with calcitonin and were mapped to peptide PROC5 (aa 96–107) Cluster B mAbs CALCA 7D4, 6H5 and 2H8 recognize katacalcin. CALCA 7D4 binds to peptide PROC4 (aa 124–134) Cluster C mAbs CALCA 4A6, 4
Novel CARs for the Treatment of Inflammatory Bowel Disease (TO 15-00795)
15-00795
FACS analysis confirmed background level activation for untransduced cells (left) and CAR-expression and activation for CDH17-CAR transduced cells (right).
The invention introduces highly specific chimeric antigen receptors (CARs) as a novel approach for the…
LS-COAT – an exceptionally efficient tumor vaccination approach (TO 15-00514)
15-00514
The administration of two well-defined compositions in liposomal vesicles with a prime-boost vaccination approach elicits a very efficient T-cell response against tumor cells, but can also be used for bacterial and viral infections. Therefore, the novel…
Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis (TO 43-00016)
43-00016
The NGS-based detection pipeline uses unique dual barcodes in PCR1 and specific dual barcodes in PCR2, enabling the simultaneous analysis of amplicons from thousands of samples within a single, rapid sequencing run…
Innovative DOTA-Linkers for Bacterial Targeting (TO 02-00324)
02-00324
DOTA-Linkers: principle of action
New DOTA derivatives with siderophore moieties have been developed to target bacterial cells more effectively. These derivatives use bacterial iron uptake systems to deliver antibiotics and other effector molecules directly into bacterial…
The Prognostic Umbilical Swab: A Rapid Molecular Risk Stratification Tool for Neonatal Sepsis and Brain Injury (TO 33-00015)
33-00015
Cq values for Enterobacteriaceae or GBS PCR and outcome of preterm infants. Each infant was categorized to the lowest Cq-value in both qPCR (Goepel et al., unpublished).
This technology introduces the first…
Programmable RNA-Guided Enzymes and Novel Orthogonal Substrates for Crispr Diagnostics (TO 02-00434)
02-00434
Programmable Cas12a2- and Cas12a3-based CRISPR diagnostics with truly orthogonal readouts for multiplex detection of ssDNA, dsDNA, or RNA.
The new Cas12a2 and Cas12a3, and their specific orthogonal substrates, improve the speed and…
