Novel Diagnostic Marker For Early Detection Of Bladder Cancer (TO 15-00604)
15-00604
Novel marker nLc4 is significantly enriched in bladder cancer patients.
Researchers from Hannover Medical School identified a strong prognostic value of the glycan Neolactotetraosylceramide (nLc4) for the detection of bladder cancer.
Bladder cancer is a…
Wireless Miniature Microscope For Near-Field Image-Capturing (TO 21-00031)
21-00031
Researchers from Leibniz Institute for Neurobiology and Otto von Guericke University Magdeburg jointly developed a novel miniature head-mounted fluorescence-microscope for near-field imaging of neuronal circuit function of living animals. Weight and size of…
Overcoming resistance - Innovative broad-spectrum inhibitors of Metallo- β-lactamases (TO 02-00376)
02-00376
Provided are innovative metallo-β-lactamase (MBL) inhibitors for combination with β lactam antibiotics showing high inhibitory activity against the three most relevant MBLs such as Imipenamase (IMP), Verona integron-encoded MBL (VIM)…
A titin-eGFP knock-in mouse model to study cardiac and skeletal muscle disorders (TO 03-00504)
03-00504
The eGFP-tagged titin protein was integrated into the sarcomere as seen by confocal imaging in cardiac tissue from both hetero- and homozygotes.
Scale bar, 10 μm.
Provided is a unique fluorescence knock-in mouse model for visualization of…
Cyclic-di-AMP: a promising adjuvant for neonatal vaccines (TO 02-00361)
02-00361
Cyclic dinucleotide compounds (CDNs), specifically c-di AMP (CDA), have been identified as being especially useful as adjuvants in therapeutic or prophylactic vaccines including usage in neonates and infants. CDNs are bacterial second messengers serving as…
A titin-DsRed knock-in mouse model to study cardiac and skeletal muscle disorders (TO 03-00495)
03-00495
Cryosections of heart tissue from homozygous titin-DsRed(Z) animals (R/R) stained for α-actinin (Z-disk) and for titin’s M-band region M8M9 to visualize titin integration. Scale bar: 10 µm
Provided is a unique fluorescence knock-in mouse…
Computed tomography (CT) imaging has become the modality of choice for the anatomic evaluation of the lung, however it lacks the capability to readily provide complex functional data such as regional perfusion blood volume (PBV) or virtual non-contrast (VNC) data. At present, obtaining regionally comparable anatomical as well as functional…
A scalable and highly sensitive assay for measuring extracellular NAD+ level in human body fluids (TO 32-00071)
32-00071
A) Implementation of the assay in Indication-dependent bionalalytics: 1. Sample generation, 2. Measurement of eNAD+ and iNAD-level, 3. Adjustment of NAD or precursor dosage based on the levelsB) Cycling principle of the…
NMDAR targeted CAAR-T cell therapy (TO 23-00069)
23-00069
Pathogenic autoantibodies against the Anti-N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) are responsible for the most common autoimmune encephalitis, a rare disease increasing in prevalence. NMDAR autoantibodies might also be at the origin of further neurologic diseases, e.g. autism…
The emergence of the novel, pathogenic SARS-CoV-2 and its rapid spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. It has been demonstrated that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the…
Bacterial infections of plants are difficult to control and their prevention and choice of resistant plant varieties is crucial. Plants evolved diverse intracellular and extracellular immune receptors to detect potentially harmful invaders directly (recognition of non-self) or indirectly through cellular perturbations (recognition of…
Monitoring and investigating disease related processes such as inflammation and cancer, requires deciphering complex cellular states. A bottleneck in this regard is the limited availability of genetic reporter systems reflecting intricate cellular states. For a first assessment, this topic may be addressed by studying the expression of a single…
Contactin1, mouse/chicken, mouse monoclonal
mAb 27-6 Hybridoma recognizing mouse, chicken homolologs
Brummendorf, T., Hubert, M., Treubert, U., Leuschner, R., Tarnok, A., and Rathjen, F. G. (1993) The axonal recognition molecule F11 is a multifunctional protein: specific domains mediate interactions with Ng-CAM and restrictin. Neuron 10,…
Automated production of cardiac organoids (TO 15-00733)
15-00733
Fig. 1: 3D-Cardiac organoid
Fig. 2: Teratogenicity assay with Thalidomide as a test compound demonstrates the known effect of Thalidomide to cause cardiac malformations during embryo development is also seen in the development of the cardiac organoids.
Novel technology for…
Treating dementia and other brain disorders with natural glycans (TO 23-00064)
23-00064
Impaired recent object recognition memory in Alzheimers’s disease model is normalized by glycan DP10: Top: 5xFAD mice treated with DP10 showed a preference for the least recently explored object (L) compared to the most recently explored object (R) in the…
One of the main causes of dependency and disability among the elderly worldwide is dementia. In 60-70% of the cases, the underlying condition of dementia is Alzheimer’s disease (AD), most frequently tauopathy. At present, only 5 medications for the treatment of AD are approved, all of which treat symptoms. The mechanism of pathogenicity in…
Ferulic acid derivatives as efficient neuroprotective agent and memory enhancer (TO 21-00027)
21-00027
FAE-20 food supplementation leaves memory in young flies unaffected yet compensates for the decline in memory of aged flies.
Ferulic acid (FA) is a common phenolic phytochemical occurring in free or bound form in plants. Previous studies…
CRISPR Switch: Inducible sgRNA expression for tightly regulated, efficient and safer CRISPR/Cas9 genome editing (TO 43-00004)
43-00004
CRISPR/Cas9 provides an easy, efficient, and affordable tool for genome editing, which has, however, certain limitations when it comes to efficiency, regulation, and off-target effects. Proven tools for…
Targeting host lipid homeostasis to augment anti-mycobacterial treatment (TO 14-00098)
14-00098
Acc2 - a novel host-directed target to interfere with Mtb growth in macrophages
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), represents one of the most prevalent infectious diseases, and is responsible for the largest fraction of…
