Autofocus-control of a microscope including an electrically tunable lens (TO 03-00459)
03-00459
Hek293AD cells displaying labeled mitochondria, imaged over 30 minutes with enabled autofocus (left and middle), and then for another 30 minutes with disabled autofocus (right). Insets show edge detection in a sub-region of the cell, emphasizing…
CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction (TO 03-00431)
03-00431
Licensing.
MDC scientist developed a web-based software tool to design highly specific sgRNA sequences for CRISPR/Cas-based gene editing.
The design of sgRNA sequences that specifically match the sequence of the target gene is a…
Method and arrangement for identification and correction of optical aberrations (TO 32-00030)
32-00030
Implementation of aberration correction within a nonlinear microscopy setup. (Source: Papadopoulos et al. 2016)
The invention introduces a novel method and arrangement for identifying and correcting optical aberrations, which significantly…
Selective Inhibitors of Genotoxic Stress Induced IKK/NFκB Pathways for Cancer Therapy (TO 03-00430)
03-00430
Inhibitors act upstream of IKK to block selectively DNA damage-induced signaling.
Many cancer therapies such as chemotherapeutics or irradiation induce cancer cell death through DNA damage and DNA double-strand break. In response to…
The advancement in gene and cell therapy in the recent years hase been tremendous and many treatments in late clinical stages with a curative potential will soon enter the market. Stable and effective integration of genes is a key element in the production of safe and affordable cell products. The drawbacks of viral systems such as retro- or…
Genome Architecture Mapping (GAM) (TO 03-00390)
03-00390
Genome Architecture Mapping (GAM). a, Discovering enhancer-promoter pairs in proximity. Bottom: example of a 2-element contact across 19Mb confirmed by DNAFISH. b-d, Schematic representation of the GAM concept.
Genome Architecture Mapping (GAM) is a novel genome-wide method for…
Novel diagnostic for Peripartum cardiomyopathy (PPCM) in pregnant women (TO 15-00411)
15-00411
Elevated PAI-1-serum and plasma levels in patients with PPCM compared to unaffected female and dilated cardiomyopathy (DCM) patients.
Extensive analysis revealed significantly elevated PAI-1 (plasminogen activator inhibitor-1) levels in PPCM…
AAV Vector Variants for Ocular Gene Delivery (TO 15-00648)
15-00648
Comparison of transduction with novel scAAV2 (M6) Cap5 capsid versus state-of-the art AAV(7m8) capsid reveals highly efficient expression of mCitrine in photoreceptor cells of the outer nuclear layer (ONL). (source: Büning et al.)
The technology describes novel variants…
