“Multiplextrode” – a completely novel electrode for analogue multiplexing (TO 21-00032)
21-00032
Researchers of Leibniz Institute of Neurobiology (LIN) have developed a novel microwire electrode for enhanced simultaneous recording of multiple neuronal signals. The novelty results from the specific pattern of electrical desheathing which…
Novel vaccine vector platform for safe and effective immunization using a replication-deficient murine cytomegalovirus (MCMV) (TO 02-00397)
02-00397
Replication-deficient murine cytomegalovirus (MCMV) for long-term immune protection. Source HZI.
The invention provides a novel vaccine vector platform for safe and effective immunization…
A FRET-based method to measure seeding activity of misfolded protein species in complex biological samples (TO 03-00471)
03-00471
The FRASE assay allows to monitor the aggregation of sensor proteins using a FRET-based readout.
Self-propagating protein aggregates are a pathological hallmark of a large number of neurodegenerative diseases…
Method and kit for early detection of preeclampsia (TO 03-00448)
03-00448
The specific marker combinations provide an in-vitro diagnostic test system (IVD) to predict the probability of the future presence or non-presence of preeclampsia at early time points in pregnancy. The metabolite-based assay can be performed on blood samples, taken…
Ultra-thin imaging fiber endoscope using a diffuser as encoder and a deep neural network as decoder (TO 99-00153)
99-00153
Scheme and principle of a diffuser endoscope. Taken from Kuschmierz et al., Light: Advanced Manufacturing, 2021, Fig. 5a, unchanged, licensed under a Creative Commons Attribution 4.0 International License,…
Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases (TO 01-01045)
01-01045
The pathogenesis of several diseases is associated with dysregulation of the cellular redox balance. This type of cell damage is referred to as ferroptosis and mediated by an increase in Fe2+ and a decrease in Fe3+.…
CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models (TO 43-00013)
43-00013
Comparison of conventional anaylsis and CRISPR-StAR in genome-wide in vivo screens. LFC correlations of overlapping genes in two batches (red: in vitro depleting; black: non-essential, grey: neutral, yellow: others (Uijttewaal et al.,…
HLA-DR-specific γδ T-cell receptor to treat proliferative disorders of HLA-DR+ cells (TO 15-00694)
15-00694
Isolation and identification of HLA-DR specific γδ TCRs in response to CMV reactivation (Deseke2022).
αβ T-cell receptor (TCRs) based immunotherapeutic approaches require prior knowledge of the HLA-haplotype in addition to the…
Best-In-Class P. aeruginosa LasB virulence factor Inhibitors (TO 02-00378)
02-00378
Antibiotic efficacy in models of P. aeruginosa infection with two different delivery methods (Konstantinovic et. al., 2023).
Best-in-class inhibitors targeting the extracellular zinc metalloprotease LasB, demonstrating exceptional activity and…
Best-in-class Darobactin derivate against Gram-negative Bacteria
(TO 02-00387)
02-00387
Survival and infection control in two models of bacterial infection (Kany et. al., 2024).
Best-in-class darobactin derivatives with exceptional antibiotic activity against Gram-negative pathogens and an innovative heterologous expression system…
INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs
(TO 01-00988)
01-00988
Scheme of the design of an INSPECT reporter system [Truong et al., Nature Cell Biology]
INSPECT reporter systems (Intron-encoded Scarless Programmable Extranuclear Cistronic Transcripts) offer…
Non-invasive and high-throughput monitoring of exon-specific isoform expression (TO 01-00986)
01-00986
This novel versatile isoform-specific expression reporter system (EXSISERS) is non-invasively quantifying cellular isoform splicing and exon usage of endogenous genes without affecting the natural splicing pattern. It signals upon…
HERV inhibitors for use in tauopathies (TO 23-00075)
23-00075
The deposition of intracellular fibrillar phosphorylated Tau in the central nervous system is a pathologic hallmark of tauopathies within the group of neurodegenerative diseases. Several lines of evidence suggest that transcellular spreading of distinct Tau aggregates may…
TCR-agnostic identification of tumor-specific T cells for cancer diagnostics and therapy (TO 15-00612)
15-00612
Innovative cancer treatments utilizing immune checkpoint inhibitors demonstrated a remarkable potency of tumor eradication by tumor-specific CD8 T cells. Due to the pharmaceutical abrogation of the immune tolerance of the…
Engineered Immune Cells to Specifically Eliminate Undesired Immune Responses (TO 15-00611)
15-00611
As a CAR-T derivative, the chimeric ligand receptor (CLR) technology comprises the opportunity to selectively eradicate target-specific immune cells from the patient’s immune system to suppress a specific undesired immune response. The…
TCR
Disclosed is Clostrubin, a pentacyclic polyphenol isolated from Clostridium beijerinckii as the first polyketide from an anaerobic organism, its unusual perifused ring system being formed in a noncanonical manner. The aromatic polyketide proved to be highly effective against various pathogenic gram-positive bacteria such as MRSA, VRE, and…
CRISPRdetect – multiplexed RNA detection with reprogrammed tracrRNAs (TO 02-00375)
02-00375
We present a scalable RNA detection platform that enables numerous applications for multiplexed diagnostics in clinical testing facilities and point-of-care (POC) testing.
Diagnostic tests are crucial for gathering information about a person’s…
High-level recombinant adeno-associated virus production (TO 32-00101)
32-00101
A: Schematic representation of proprietary triple-infection protocol; B: Yields (burst sizes) of affinity purified rAAV-2 preperations.
The invention comprises a highly efficient methodology for high-level production of adeno-associated virus (AAV) vectors for…
First-in-Class S. aureus α-Hemolysin Inhibitors for Lung and Skin Infections (TO 02-00373)
02-00373
Survival in a mouse model of S.aureus infection (Shekhar et. al., 2025).
First-in-class inhibitors of virulence factor α-hemolysin for the prophylaxis and treatment of lung (HAP/VAP) and skin infections (atopic…
