Aggregates of α-synuclein (α-syn) are characteristic of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD), Lewy body dementia, and multiple system atrophy (MSA). There is currently no known therapy with proven efficacy to slow or halt the progression of synucleinopathies. Therefore, the development of new…
Diffuse large B-cell lymphomas (DLBCL) exhibit high degree of genetic heterogeneity. MyD88L265P is a prominent genetic aberration responsible for fostering tumor growth in this heterogenous lymphoma entity. In particular 17% of DLBCL and 42% in primary central nervous system lymphoma (PCNSL) patients carry the oncogenic mutation. The resulting…
Acoustic hearing implants usually generate sound with electro-magnetic or piezo actuators. Alternatively, optoacoustic generation of sound can be achieved by irradiating the cochlea with laser pulses. This method constitutes a promising alternative treatment option for sensorineural hearing loss and combined electro-acoustic stimulation. However,…
Electrocorticography (ECoG) is a key technology for mapping neural interactions and analysis of brain functions. Within the last years miniaturization of ECoG arrays with smaller electrodes strongly reduced spacing while the spatial and temporal resolution of recorded neuronal signalling has tremendously increased. Now, emerging technologies like…
In heart disease pressure-volume overload conditions trigger cardiac remodeling which can lead to hypertrophy, heart failure and arrhythmias with risk for sudden cardiac death. However, there is large variability how patients deal with overload. Furthermore, neither the onset of clinical symptoms nor the degree of hypertrophy (chamber size, wall…
FLAM-Seq: Genome-wide full-length mRNA and poly(A)-tail sequencing (TO 03-00470)
03-00470
Underlying principle for Full-length poly(A) and mRNA sequencing: FLAM-seq (Legnini et al., 2019).
Detailed information about mRNA isoform expression including respective poly(A)-tail sequence (actual sequence length and sequence composition) is…
Treatment with blood products is driven by information and is highly regulated in medicine worldwide. Severe adverse events (SAE) due to "never events" (process errors supposed to never ever occur), however, indicate that guidelines and written rules do not always meet implementation. "Never events" due to process errors include wrong decision…
Metax: Cross-Domain Metagenomic Profiling Technology (TO 02-99999)
02-99999
Metax taxonomy profiling with coverage information: The workflow integrates coverage metrics with probabilistic modeling to estimate species abundance. Artifact signals from contamination, kitome DNA, and shared genetic elements are flagged, while true taxa are…
The specific targeting of malignant blood cells or autoreactive plasma cells with minimal effects on other cell types is still a challenge in the therapy of haematological malignancies or autoimmune diseases. Multiple Myeloma (MM), a cancer of plasma cells accumulating in the bone marrow, accounts for approximately 1% of all neoplasms worldwide…
Many bacterial pathogens are surrounded by a thick capsule composed of a network of high-molecular weight polysaccharides. This layer of polymers not only ensures survival by physical means, but represents a crucial virulence factor of different bacterial species. As bacterial capsules directly interact with its host’s immune system their…
Predicting the therapeutic effect of compositions containing BH3 mimetics (TO 15-00502)
15-00502
Response to treatment with venetoclax in primary ALL and CLL cells (at initial diagnosis) while primary healthy and CML cells show no induction of apoptosis.
BH3 mimetics are a novel class of therapeutics for improved cancer therapy, with a focus…
Novel Therapy for Treatment of Alzheimer´s Disease (TO 21-00035)
21-00035
(A) Unphosphorylated Jacob displaces LMO4 from CREB. Nitarsone blocks binding of Jacob and LMO4. (B) Nitarsone rescues short-term memory impairment in Y-maze object recognition task in an AD mouse model. (Grochowska, Kreutz et al., 2023)
The presented invention reveals…
Acute liver failure is a life threatening condition which is based on necrosis of hepatocytes and leads to subsequent liver- and multi-organ-failure. The most common etiologies for acute liver failure (ALF) are drug induced toxicity (<70 %) and viral infections (<10 %). Amongst them, Acetaminophen (APAP, paracetamol) overdose has emerged as…
Genetically Manipulated Cornea for Transplantation (TO 15-00538)
15-00538
Corneas transduced with shRNA expression cassettes specific for silencing β2-microglobulin (shβ2m) or alpha-chain of H2E (shH2Ea) or CIITA (shCIITA). Results are compared to non-transduced corneas and corneas transduced with control shRNA (shNS) and show an effective…
3D-Seq: Localizing Spatial Gene Expression in 3-Dimensions on Single Cell-Level (TO 03-00462)
03-00462
3D-Seq approach.
Spatial cellular information is crucial for understanding the complex crosstalk and communication between neighbouring cell-types during tissue development, differentiation, and homeostasis. Researchers of the Berlin…
Highly active Chlorotonil A Derivatives for the treatment of Malaria (TO 02-00354)
02-00354
Improved Chlorotonil A (left) and B (right) Derivatives.
Chlorotonil derivatives with enhanced water solubility and bioavailability have been developed to effectively target malaria, particularly its gametocyte stage. These novel macrolides exhibit…
Novel treatment for sepsis in newborns (TO 15-00461b)
15-00461b
Cord blood levels of S100A8/A9 are inversely correlated with the risk of sepsis in human neonates. (a) Serum levels of S100A8/A9 in cord blood samples from term and preterm human newborns. (b) Cord blood levels of S100A8/A9 in preterm newborns without LONS (late-onset neonatal…
Green Rodenticide - Use of a Grayanotoxin-Based Agent for Rodent Control (TO 99-00211)
99-00211
Green rodent control
The technology provides a novel rodenticide concept using grayanotoxins - natural, biodegradable neurotoxins - obtained from plant extracts as highly effective non-anticoagulant acting rodenticides. The compounds can be…
Advances in genome sequencing and targeted editing technologies have enhanced the feasibility of genome engineering approaches, especially with respect to potential future therapeutic applications. Nevertheless, there are still major limitations in terms of editing efficiencies and broad access to relevant and desired cell types. Current cell…
Novel Labyrinthopeptins as anti-viral agents (TO 02-00337)
02-00337
Chemical stereostructure of labyrinthopeptin A1
Novel labyrinthopeptins, a class of lantibiotics containing the rare amino acid labionin, have been developed as potent antiviral agents. These ribosomally synthesized peptides, produced by specific bacterial strains,…
