Prediction of L-Asparaginase resistance in tumor therapy (TO 15-00751)
15-00751
SOD2 activity and L-Asparaginase sensitivity in drug-resistant acute lymphoblastic leukemia.
Asparaginase treatment has been a major driver of improved clinical outcomes in T-cell and B-cell acute lymphoblastic leukemias (T-ALL and B-ALL) and it also demonstrated…
Novel inhibitors of Cytomegalovirus
(TO 02-00402)
02-00402
Mechanism and binding site to inhibit human cytomegalovirus (HCMV) infection (Unpublished)
First-in-class, small-molecule inhibitors targeting cytomegalovirus (CMV) with a novel structure and mechanism of action. The technology is particularly effective against human…
Maintenance of regulatory T cell phenotype by expression of IL-2 fusion protein (TO 15-00740)
15-00740
Expression of IL-2 fusion protein enhanced CAR-Treg survival in an IL-2-limiting environment (Kremer et al., 2022).
A new and promising approach for the treatment of transplant patients and for autoimmune diseases is the adoptive transfer…
Next generation allogeneic CAR-NK cell platform for treatment of malignant diseases (TO 32-00076)
32-00076
CAR-NK Platform Technology
This innovative platform offers "off-the-shelf" CAR-NK cells with extensive applicability against solid tumors and hematological cancers. The resulting cell products are designed to overcome significant…
Efficient, adjuvant-free mucosal vaccination via IgA feedback loop (TO 14-00176)
14-00176
The human body is constantly exposed to a myriad of pathogens and toxins, with the mucosa of the skin, respiratory system, and intestinal tract serving as the primary interface between the environment and the body’s sterile interior. This barrier,…
Rapid Detection of Shiga toxin producing E.coli (STEC) (TO 02-00413)
02-00413
Fig.1: Principle of an enzymatic assay based on Stx N-glycosidase activity
(Source: Ramming et al. 2023, doi: https://doi.org/10.1101/2023.10.12.562006)
This novel assay allows fast functional detection of Shiga toxin-producing E. coli (STEC) in…
Bioartificial vascular grafts based on a highly compacted acellular fibrin matrix (TO 15-00433)
15-00433
(A) Fibrin prosthesis implanted as aorto-coronary bypass in a sheep for evaluation studies. (B) Histological HE-staining of explanted fibrin grafts, which were implanted in a long-term in vivo-study, visualizes the remodeling process of…
Immunosuppressant resistance in anti-viral T cell products (TO 32-00083)
32-00083
Fig 1. Testing of CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for ATT in human based lung organoids (modified after Amini et al., 2021)
The present invention provides an innovative approach for the treatment of life-threatening…
Blood-based tuberculosis precision medicine: transcriptomic model predicts treatment response (TO 14-00169)
14-00169
Tuberculosis (TB) remains a major global health problem, aggravated by the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB)…
Replacement of allergen challenge: Safely scoring prevalence & severity of allergies (TO 14-00173)
14-00173
Allergies have become the most common chronic disease in Western countries, afflicting about 30% of the population. Although symptomatic treatments are available, many patients are not diagnosed correctly, as common skin prick…
Expansion of pancreatic progenitors derived from human pluripotent stem cells und GMP-compliant conditions (TO 01-01085)
01-01085
While differentiation of human pluripotent stem (hPS) cells into pancreatic islets could provide an unlimited source of β-cells for transplantation and personalized medicine, numerous obstacles remain. These…
Sleeping Beauty transposase variants with increased safety due to reduced half-life (TO 03-00539)
03-00539
Gene therapies are associated with great expectations, as they have the potential to cure a wide range of diseases. However, therapeutic success does not only depend on the simplicity, cost-efficiency, and scalability, but also…
Keratinophile photosensitizers for safe and rapid treatment of onychomycosis (TO 44-00013)
44-00013
Onychomycosis, commonly known as nail fungus, is a prevalent health problem affecting millions of people worldwide. It is caused by fungal infection of the nail bed and plate, leading to thickened, discolored, and brittle nails. The condition…
Drug combinations to overcome therapy resistance in cancer (TO 01-01080)
01-01080
In order to provide therapies for the treatment of diseases associated with tyrosine kinase receptor (TKR) activation, TKR inhibitors have been developed. Medullary Thyroid Carcinoma (MTC), a rare tumor of the thyroid gland, is an example for a disease…
The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer (TO 32-00164)
32-00164
Fig. 1: Targeted adaptation of a homing chemokine system for chimeric antigen receptor (CAR) T-cell products: CONAN (Schmück-Henneresse Lab)
The invention comprises a novel strategy for enhancing Chimeric Antigen Receptor (CAR) T cell migration…
CD3-CAR NK-92 cell-mediated TCR+ depletion (TO 32-00124)
32-00124
Fig. 1 A: Manufacturing of allogeneic “off-the-shelf” CAR T cells by means of TCR/CD3-specific CAR NK-92 cell lines for the removal of residual TCR+ AT-cells from TCR-deleted CAR T-cell product. B: CAR NK-92 cells allowed to produce TCR– CAR T cells with <0.01% TCR+ T…
Nutritional compositions for treating dysfunction of liver fat metabolism – VAFD (TO 11-00065)
11-00065
Vitamin-A Fasting Diet (VAFD) rescues impairments in liver fat metabolism, thereby reducing the risk of cirrhosis, liver cancer, hyperlipidaemia, cardio-vascular disease, and muscle loss (sarcopenia), @Rudolph
Here we provide the…
Novel Lectin-Targeting therapeutics and diagnostics for Pseudomonas aeruginosa infections
(TO 02-00396)
02-00396
Diagnostic approach using the antibiotic prodrug (modified from Zahorska et al. and Meiers et al.)
Three distinct approaches targeting bacterial lectins LecA and LecB, critical components in the biofilm formation of…
Prediction for targeting efficiency of guide RNA for a gene of interest in bacteria (TO 02-00380)
02-00380
Workflow of prediction of guide efficiency [Yu et al. 2022, modified]
Provided is a machine learning-based tool that improves reliable prediction of targeting efficiency of guide RNA for gene silencing in bacteria.
CRISPR interference…
