Method for high-yield production of megakaryocytes (TO 15-00555)
15-00555
Researchers from Hannover Medical School successfully developed a novel process for effective production of megakaryocytes from induced pluripotent stem cells (iPSCs).
Blood thrombocytes (platelets) are produced from megakaryocytes and are essential for blood…
Spacer-nick genome editing of hematopoietic stem and progenitor cells and T cells (TO 03-00481)
03-00481
Correction of the HBB locus with a pair of optimized sgRNA. HDR represents gene correction efficiency.
A novel method to correct a broad range of mutations in human hematopoietic stem and progenitor cells (HSPC) and T cells is provided.…
Short Term Isotope Pulse Labeling Method for Analyzing Metabolic States and Drug Targets in Biological Samples (TO 03-00384)
03-00384
Scheme of a possible pSIRM experiment to measure the direct response after a drug treatment and later adaptive changes of metabolism (S. Kempa, Max-Delbrück-Center).
Here we present pulsed stable isotope…
Blood-based tuberculosis precision medicine: transcriptomic model shortens therapy duration (TO 14-00128)
14-00128
ROC curves for therapy end detection. Proprietary transcrisptomic model (TEM): black; known published models: colored (from Heyckendorf et al., 2021)
Tuberculosis (TB) remains a major global health problem that is further…
Epigenetic detection of early-stage non-small cell lung cancer in blood (TO 14-00135)
14-00135
Lung cancer is the leading cause of cancer-related death worldwide, with non-small cell lung cancer (NSCLC) being the predominant morphology and adenocarcinoma (AC) the most common histology. Choosing the appropriate therapy depends on early and…
Self-Organizing Human 2D Neuromuscular Junction Model and 3D Neuromuscular Organoids (TO 03-00493)
03-00493
Novel human neuromuscular organoids (NMOs) are provided that can be maintained in 3D culture for several months. HPSC-derived neuromesodermal progenitors (NMP) simultaneously generate spinal cord neurons and skeletal muscle cells…
Novel gas flow system for high throughput determination of oxygen dissociation curves (ODC) (TO 42-00036)
42-00036
ODC plate - All wells are interspaced with a black polymer, and channels milled to form a meandering gas flow system when covered with a transparent seal.
On behalf of Medical University of Innsbruck, we offer a new method for…
Phytosphingosine Derivatives as Adjuvants in Immune Stimulation (TO 02-00374)
02-00374
Improved immune stimulation by novel phytosphingosine derivatives used as mucosal or parenteral adjuvants.
Adjuvants are used in several vaccines to create a stronger immune response after vaccination. Currently, only a few adjuvants are approved for the…
Flow cytometric basophil activation test for automated, high-throughput allergy diagnostics (TO 14-00142)
14-00142
Ring trial proving BAT's robustness (Behrends et al., 2021).
Allergies have become the most common chronic disease in Western countries. Although symptomatic treatments may exist, many patients are not diagnosed correctly, as…
Dental implants are widely used as safe and long-lasting dental prostheses for the replacements of missing teeth. In contrast to removable dentures or bridges between adjacent teeth, dental implants harbour the advantage of preserving surrounding gingival and bone structures. However, post-implantation inflammatory processes remain a major…
Non-invasive pressure gradient prediction for a cardiovascular narrowing (TO 32-00081)
32-00081
Non invasive method to predict cariovascular pressure drops at coartation or stenontic heart valves for rest or stress situations.
This non-invasive method allows the determination of pressure gradients at a cardiovascular narrowing like…
Biodynamers enhance drug delivery (TO 02-00369)
02-00369
Drug delivery of anionic molecules such as nucleic acids or anionic proteins is enhanced using new cationic biodynamers. Delivery of cationic proteins can be improved with anionic biodynamers, respectively.
Safe and efficient delivery of nucleotides e.g. mRNA is essential for gene…
Expansion of a (G4C2) hexanucleotide repeat upstream of the C9orf72 coding region is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9orf72 cases show nuclear foci of sense and antisense repeat RNA transcripts and unique aggregates of dipeptide repeat (DPR) proteins resulting in abundant…
SARSeq: Multiplexed, parallel detection of SARS-CoV2 variants and other viruses in high-throughput (TO 43-00016)
43-00016
NGS-based detection pipeline. Unique dual well-barcodes in PCR1, and specific plate-barcodes in PCR2, allow for simultaneous analysis of amplicons derived from thousands of samples in a single, rapid NGS run (from…
Cystobactamids – novel antibacterials against gram-negative pathogens (TO 02-00311)
02-00311
Cystobactamid 861-2
Provided are cystobactamids, a group of newly discovered natural products isolated from Cystobacter spec., that show strong antibacterial activity against a variety of gram-positive and gram-negative pathogens, by inhibiting the…
Novel Diagnostic Marker For Early Detection Of Bladder Cancer (TO 15-00604)
15-00604
Novel marker nLc4 is significantly enriched in bladder cancer patients.
Researchers from Hannover Medical School identified a strong prognostic value of the glycan Neolactotetraosylceramide (nLc4) for the detection of bladder cancer.
Bladder cancer is a…
Wireless Miniature Microscope For Near-Field Image-Capturing (TO 21-00031)
21-00031
Researchers from Leibniz Institute for Neurobiology and Otto von Guericke University Magdeburg jointly developed a novel miniature head-mounted fluorescence-microscope for near-field imaging of neuronal circuit function of living animals. Weight and size of…
Overcoming resistance - Innovative broad-spectrum inhibitors of Metallo- β-lactamases (TO 02-00376)
02-00376
Provided are innovative metallo-β-lactamase (MBL) inhibitors for combination with β lactam antibiotics showing high inhibitory activity against the three most relevant MBLs such as Imipenamase (IMP), Verona integron-encoded MBL (VIM)…
A titin-eGFP knock-in mouse model to study cardiac and skeletal muscle disorders (TO 03-00504)
03-00504
The eGFP-tagged titin protein was integrated into the sarcomere as seen by confocal imaging in cardiac tissue from both hetero- and homozygotes.
Scale bar, 10 μm.
Provided is a unique fluorescence knock-in mouse model for visualization of…
Cyclic-di-AMP: a promising adjuvant for neonatal vaccines (TO 02-00361)
02-00361
Cyclic dinucleotide compounds (CDNs), specifically c-di AMP (CDA), have been identified as being especially useful as adjuvants in therapeutic or prophylactic vaccines including usage in neonates and infants. CDNs are bacterial second messengers serving as…
