Novel ASO-Based mRNA Silencing Technology for Phage-Host Interaction Research (TO 02-00432)
02-00432
Antisense oligomers (ASO) are taken up by the bacterial cell mediated by cell penetrating peptides (CPPs). After phage infection, ASOs bind specific phage transcripts and prevent translation. If the protein encoded by the target phage mRNA is…
NICHE-CAR-T: NR2F6 Immune Checkpoint Harnessing to Enhance CAR-T efficacy (TO 42-00076)
42-00076
While CAR-T therapies have revolutionized treatment for hematological cancers, their efficacy in solid tumors remains limited due to both an immunosuppressive tumor immune microenvironment (TIME) leading to terminal T cell dysfunction and an…
Novel therapy approach for treatment of lung fibrosis (TO 01-01036)
01-01036
A: Intrapleural administration of a fluorescence label (NHS-FITC) for labeling the ECM of the lung and analysis of the surface ECM labeling after 14 days. B: After an intrapleural administration of the molecular fluorescence label (NHS-FITC) bleomycin is injected.…
Method for tuning brain network models for the implementation of brain digital twins (TO 32-00123)
32-00123
Left: For tuning BNMs, long-range white matter couplings between every pair of BNM nodes have been taken into consideration.
Right: Empirical (here: functional MRI-based; upper triangular portion of the matrix) versus…
Biomarker Panel for Diagnosing Pulmonary Dysfunction (TO 15-00652)
15-00652
The invention refers to a novel biomarker panel comprising marker genes for an earlier and more accurate diagnosis of pulmonary dysfunction after lung transplantation, in particular chronic lung allograft dysfunction (CLAD). CLAD is mainly caused by Bronchiolitis…
DeColi: Gut Decolonization of Multi-Resistant Escherichia coli (TO 02-00423)
02-00423
This invention introduces a novel probiotic-based method that utilizes specific commensal Escherichia coli strains to target and remove multidrug-resistant (MDR) E. coli from the gut. Unlike existing treatments, it offers a non-antibiotic solution,…
An engineered serine integrase for targeted gene transfer in human cells (TO 32-00202)
32-00202
Fig. 1 Improving non-viral tools for larger transgenes and potentially independence of HDR (provided by Wagner Lab)
Researchers of Charité developed a novel gene editing technology that utilizes an engineered serine integrase to enable insertion…
Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out (TO 32-00192)
32-00192
Fig. 1 The BEKI platform is highly amenable for multiplexing, with reduced toxicity and off-target effects, and allows optimization of manufacturing as only a single transfection is needed (provided by Wagner Lab)
Researchers at…
A novel immuno-oncology approach for induction and massive amplification of antigen-specific cytotoxic CD8+ T-cells (TO 32-00099)
32-00099
Principle of the technology. Source: R. Kroczek
The technology has a unique therapeutic potential in immunological tumor therapy as it can induce powerful cytotoxic immunity against viral antigens or…
Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform (TO 33-00002)
33-00002
Acute-phase proteins are common components of blood, whose plasma concentrations alters in response to inflammation and/or infection. They play pivotal roles in the immune response, and serve as biomarkers in clinical…
HSV signature antibodies predict the development of anti-NMDA receptor encephalitis (TO 32-00187)
32-00187
Fig. 1 HSV signature antibodies are associated with NMDARE development (modified after J. Kreye),
Researchers of Charité and Johns Hopkins University developed a technology that utilizes newly identified biomarkers to quantify the…
Biomarker set for early and non-invasive diagnosis and differentiation of renal cell carcinomas (TO 43-00034)
43-00034
Performance of the UrineScore in diagnosing and differentiating renal cell carinomas. Source: patent application
Clear cell renal cell carcinoma (ccRCC) is the most common subtype among all renal malignancies and has the…
Efficient multiplex cryo-embedding method for cost-efficient, high-throughput tissue analysis (TO 43-00026)
43-00026
Efficient multiplexed cryo-sectioning. A-C, steps of tissue embedding in a 6x3 grid. D, whole-slide stitched microscopy image of immunostaining for e-cadherin, MAP2, CK19 and DAPI. Individual tissues are labeled within the…
Drug Dosage Optimization Based on Machine Learning and Mechanistic Modeling (TO 02-00430)
02-00430
Figure1. Experimental results of PA biofilm treatment with Tobramycin. (a) shows the concentration of antibiotics in time. The green line corresponds to the constant treatment and blue line to the dosage deployment pattern suggested by results…
Dream Complex Inhibitors for Treating Medical Conditions Induced by Circadian Rhythm Disruption (TO 11-00068)
11-00068
DREAM complex model showing the mechanism of action to induce the restaurative effect wihtout modifying sleeping patterns (modified from Santos Valentim et. al., 2025).
PER1-targeting siRNA or Harmine-like inhibitors restore…
Diagnostic assay for determination of personal microbial metabolite production profile for nutritional adjustment (TO 03-00523)
03-00523
The RT-PCR microbiome profiling kit provides an individual picture of metabolite production potential in the human gut microbiome that reflects personal health status as well as diet and lifestyle…
VSV-encoded HCV vaccines that induce broadly neutralising antibodies against Hepatitis C (TO 18-00054)
18-00054
Sera of GT2a.J6 immunized mice contain cross-neutralizing antibodies against a broad spectrum of HCV biotypes.
Due to the extraordinary diversity and flexibility of Hepatitis C Virus (HCV) as well as different immune evasion…
