A titin-DsRed knock-in mouse model to study cardiac and skeletal muscle disorders (TO 03-00495)
03-00495
Cryosections of heart tissue from homozygous titin-DsRed(Z) animals (R/R) stained for α-actinin (Z-disk) and for titin’s M-band region M8M9 to visualize titin integration. Scale bar: 10 µm
Provided is a unique fluorescence knock-in mouse…
Computed tomography (CT) imaging has become the modality of choice for the anatomic evaluation of the lung, however it lacks the capability to readily provide complex functional data such as regional perfusion blood volume (PBV) or virtual non-contrast (VNC) data. At present, obtaining regionally comparable anatomical as well as functional…
A scalable and highly sensitive assay for measuring extracellular NAD+ level in human body fluids (TO 32-00071)
32-00071
A) Implementation of the assay in Indication-dependent bionalalytics: 1. Sample generation, 2. Measurement of eNAD+ and iNAD-level, 3. Adjustment of NAD or precursor dosage based on the levelsB) Cycling principle of the…
NMDAR targeted CAAR-T cell therapy (TO 23-00069)
23-00069
Pathogenic autoantibodies against the Anti-N-Methyl-D-Aspartate (NMDA) receptor (NMDAR) are responsible for the most common autoimmune encephalitis, a rare disease increasing in prevalence. NMDAR autoantibodies might also be at the origin of further neurologic diseases, e.g. autism…
The emergence of the novel, pathogenic SARS-CoV-2 and its rapid spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. It has been demonstrated that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the…
Bacterial infections of plants are difficult to control and their prevention and choice of resistant plant varieties is crucial. Plants evolved diverse intracellular and extracellular immune receptors to detect potentially harmful invaders directly (recognition of non-self) or indirectly through cellular perturbations (recognition of…
Monitoring and investigating disease related processes such as inflammation and cancer, requires deciphering complex cellular states. A bottleneck in this regard is the limited availability of genetic reporter systems reflecting intricate cellular states. For a first assessment, this topic may be addressed by studying the expression of a single…
Contactin1, mouse/chicken, mouse monoclonal
mAb 27-6 Hybridoma recognizing mouse, chicken homolologs
Brummendorf, T., Hubert, M., Treubert, U., Leuschner, R., Tarnok, A., and Rathjen, F. G. (1993) The axonal recognition molecule F11 is a multifunctional protein: specific domains mediate interactions with Ng-CAM and restrictin. Neuron 10,…
Automated production of cardiac organoids (TO 15-00733)
15-00733
Fig. 1: 3D-Cardiac organoid
Fig. 2: Teratogenicity assay with Thalidomide as a test compound demonstrates the known effect of Thalidomide to cause cardiac malformations during embryo development is also seen in the development of the cardiac organoids.
Novel technology for…
Treating dementia and other brain disorders with natural glycans (TO 23-00064)
23-00064
Impaired recent object recognition memory in Alzheimers’s disease model is normalized by glycan DP10: Top: 5xFAD mice treated with DP10 showed a preference for the least recently explored object (L) compared to the most recently explored object (R) in the…
One of the main causes of dependency and disability among the elderly worldwide is dementia. In 60-70% of the cases, the underlying condition of dementia is Alzheimer’s disease (AD), most frequently tauopathy. At present, only 5 medications for the treatment of AD are approved, all of which treat symptoms. The mechanism of pathogenicity in…
Ferulic acid derivatives as efficient neuroprotective agent and memory enhancer (TO 21-00027)
21-00027
FAE-20 food supplementation leaves memory in young flies unaffected yet compensates for the decline in memory of aged flies.
Ferulic acid (FA) is a common phenolic phytochemical occurring in free or bound form in plants. Previous studies…
CRISPR Switch: Inducible sgRNA expression for tightly regulated, efficient and safer CRISPR/Cas9 genome editing (TO 43-00004)
43-00004
CRISPR/Cas9 provides an easy, efficient, and affordable tool for genome editing, which has, however, certain limitations when it comes to efficiency, regulation, and off-target effects. Proven tools for…
Targeting host lipid homeostasis to augment anti-mycobacterial treatment (TO 14-00098)
14-00098
Acc2 - a novel host-directed target to interfere with Mtb growth in macrophages
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), represents one of the most prevalent infectious diseases, and is responsible for the largest fraction of…
Aggregates of α-synuclein (α-syn) are characteristic of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD), Lewy body dementia, and multiple system atrophy (MSA). There is currently no known therapy with proven efficacy to slow or halt the progression of synucleinopathies. Therefore, the development of new…
Diffuse large B-cell lymphomas (DLBCL) exhibit high degree of genetic heterogeneity. MyD88L265P is a prominent genetic aberration responsible for fostering tumor growth in this heterogenous lymphoma entity. In particular 17% of DLBCL and 42% in primary central nervous system lymphoma (PCNSL) patients carry the oncogenic mutation. The resulting…
Acoustic hearing implants usually generate sound with electro-magnetic or piezo actuators. Alternatively, optoacoustic generation of sound can be achieved by irradiating the cochlea with laser pulses. This method constitutes a promising alternative treatment option for sensorineural hearing loss and combined electro-acoustic stimulation. However,…
Electrocorticography (ECoG) is a key technology for mapping neural interactions and analysis of brain functions. Within the last years miniaturization of ECoG arrays with smaller electrodes strongly reduced spacing while the spatial and temporal resolution of recorded neuronal signalling has tremendously increased. Now, emerging technologies like…
In heart disease pressure-volume overload conditions trigger cardiac remodeling which can lead to hypertrophy, heart failure and arrhythmias with risk for sudden cardiac death. However, there is large variability how patients deal with overload. Furthermore, neither the onset of clinical symptoms nor the degree of hypertrophy (chamber size, wall…
