Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases (TO 01-01045)
01-01045
The pathogenesis of several diseases is associated with dysregulation of the cellular redox balance. This type of cell damage is referred to as ferroptosis and mediated by an increase in Fe2+ and a decrease in Fe3+.…
CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models (TO 43-00013)
43-00013
Comparison of conventional anaylsis and CRISPR-StAR in genome-wide in vivo screens. LFC correlations of overlapping genes in two batches (red: in vitro depleting; black: non-essential, grey: neutral, yellow: others (Uijttewaal et al.,…
HLA-DR-specific γδ T-cell receptor to treat proliferative disorders of HLA-DR+ cells (TO 15-00694)
15-00694
Isolation and identification of HLA-DR specific γδ TCRs in response to CMV reactivation (Deseke2022).
αβ T-cell receptor (TCRs) based immunotherapeutic approaches require prior knowledge of the HLA-haplotype in addition to the…
Best-In-Class P. aeruginosa LasB virulence factor Inhibitors (TO 02-00378)
02-00378
Antibiotic efficacy in models of P. aeruginosa infection with two different delivery methods (Konstantinovic et. al., 2023).
Best-in-class inhibitors targeting the extracellular zinc metalloprotease LasB, demonstrating exceptional activity and…
Best-in-class Darobactin derivate against Gram-negative Bacteria
(TO 02-00387)
02-00387
Survival and infection control in two models of bacterial infection (Kany et. al., 2024).
Best-in-class darobactin derivatives with exceptional antibiotic activity against Gram-negative pathogens and an innovative heterologous expression system…
INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs
(TO 01-00988)
01-00988
Scheme of the design of an INSPECT reporter system [Truong et al., Nature Cell Biology]
INSPECT reporter systems (Intron-encoded Scarless Programmable Extranuclear Cistronic Transcripts) offer…
Non-invasive and high-throughput monitoring of exon-specific isoform expression (TO 01-00986)
01-00986
This novel versatile isoform-specific expression reporter system (EXSISERS) is non-invasively quantifying cellular isoform splicing and exon usage of endogenous genes without affecting the natural splicing pattern. It signals upon…
HERV inhibitors for use in tauopathies (TO 23-00075)
23-00075
The deposition of intracellular fibrillar phosphorylated Tau in the central nervous system is a pathologic hallmark of tauopathies within the group of neurodegenerative diseases. Several lines of evidence suggest that transcellular spreading of distinct Tau aggregates may…
TCR-agnostic identification of tumor-specific T cells for cancer diagnostics and therapy (TO 15-00612)
15-00612
Innovative cancer treatments utilizing immune checkpoint inhibitors demonstrated a remarkable potency of tumor eradication by tumor-specific CD8 T cells. Due to the pharmaceutical abrogation of the immune tolerance of the…
Engineered Immune Cells to Specifically Eliminate Undesired Immune Responses (TO 15-00611)
15-00611
As a CAR-T derivative, the chimeric ligand receptor (CLR) technology comprises the opportunity to selectively eradicate target-specific immune cells from the patient’s immune system to suppress a specific undesired immune response. The…
TCR
Disclosed is Clostrubin, a pentacyclic polyphenol isolated from Clostridium beijerinckii as the first polyketide from an anaerobic organism, its unusual perifused ring system being formed in a noncanonical manner. The aromatic polyketide proved to be highly effective against various pathogenic gram-positive bacteria such as MRSA, VRE, and…
CRISPRdetect – multiplexed RNA detection with reprogrammed tracrRNAs (TO 02-00375)
02-00375
We present a scalable RNA detection platform that enables numerous applications for multiplexed diagnostics in clinical testing facilities and point-of-care (POC) testing.
Diagnostic tests are crucial for gathering information about a person’s…
High-level recombinant adeno-associated virus production (TO 32-00101)
32-00101
A: Schematic representation of proprietary triple-infection protocol; B: Yields (burst sizes) of affinity purified rAAV-2 preperations.
The invention comprises a highly efficient methodology for high-level production of adeno-associated virus (AAV) vectors for…
First-in-Class S. aureus α-Hemolysin Inhibitors for Lung and Skin Infections (TO 02-00373)
02-00373
Survival in a mouse model of S.aureus infection (Shekhar et. al., 2025).
First-in-class inhibitors of virulence factor α-hemolysin for the prophylaxis and treatment of lung (HAP/VAP) and skin infections (atopic…
Rapid quantitation of virus-neutralizing antibodies in biosamples - a novel BSL1 approach based on virus-like particles (VLPs) (TO 01-01030)
01-01030
Serum, saliva and other body fluids of virus-infected individuals contain virus-specific antibodies, which are important diagnostic biomarkers. The functions of these antibodies may vary, but…
Tyrolian algae extract with anti-inflammatory potential (TO 42-00047)
42-00047
Glucocorticoids are usually used in the treatment of various skin conditions and diseases which cause damaging inflammatory reactions. While these compounds represent a significant milestone in dermatologic therapy through their beneficial effects in reducing…
Next-Generation Probiotics (TO 02-00385)
02-00385
Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae. Source: L Osbelt et al., Cell Host & Microbe, 2021
The novel probiotic consists of special strains of Klebsiella oxytoca combined with at least three additional commensal bacteria. This probiotic…
microRNA Signature Indicates Risk for Cognitive Decline (TO 23-00046)
23-00046
Minimally invasive, blood-based detection of a 3-miRNA signature that enables early identification of individuals at risk for cognitive decline, before clinical symptoms appear.Adapted from: Islam, Md Rezaul et al. EMBO Molecular Medicine, e13659, 11 Oct 2021.
A…
The physiological breast-milk proteins S100A8 and S100A9 promote an eubiotic gut state in infants (TO 15-00461a)
15-00461a
Instantly after birth, every newborn is exposed and must adapt to a variety of pathogenic and non-pathogenic microorganisms. Feeding a newborn with mother’s milk supports the immune system to adopt to the environmental…
