INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

Metax: Cross-Domain Metagenomic Profiling Technology

Autofocus-control of a microscope including an electrically tunable lens

3D-Seq: Localizing Spatial Gene Expression in 3-Dimensions on Single Cell-Level

Cytotoxicity Assay for detecting Cellular Damage

Novel Diagnostic Marker For Early Detection Of Bladder Cancer

Method and arrangement for identification and correction of optical aberrations

A scalable and highly sensitive assay for measuring extracellular NAD+ level in human body fluids

The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

Efficient Generation of Murine Brain Organoids from Adult Neural Stem Cells

Mice with Kidney-specific Megalin Gene Defect

Kinin B1 Receptor Knock-Out Mice

Double-Transgenic Rats as a Tool to Study the Function of the Renin-Angiotensin System

Tryptophan Hydroxylase 1 Knockout Mice as a Tool to Study the Function of Serotonin

TGR(hKLK1) Transgenic rats as a Tool to Study the Kallikrein-Kinin System

Angiotensinogen Transgenic Mice TGM(rAOGEN)123

Renin Transgenic Rat TGR(mREN2)27

Conductin+/lacZ-mice as a model for Wnt-mediated tumorigenesis

CCR7 -/- mice: a model for studies on early immune reponses towards alloantigens

SLP3 mutant mice; an animal model lacking touch-evoked neuropathic pain

Animal model for endotoxic shock: transgenic rats with endothelial overexpression of kinin B1 receptors

A titin-DsRed knock-in mouse model to study cardiac and skeletal muscle disorders

A titin-eGFP knock-in mouse model to study cardiac and skeletal muscle disorders

Lifespan predictor - Reliable deep learning tool for in vivo lifespan prediction

SCON – Artificial intron devoid of hypomorphic target gene effects for one-step generation of conditional animal models

Plasma cell-specific antibodies targeting BCMA for the treatment of multiple myeloma and autoimmune diseases

Advancing Bioproduction: HDLBP overexpression enhances protein production and secretion

Broadly neutralizing antibodies against hepatitis E virus (HEV)

Contactin1, mouse/chicken, mouse monoclonal

WarpDemuX - Method for Demultiplexing of RNA-sequencing DATA

Metax: Cross-Domain Metagenomic Profiling Technology

CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction

Lifespan predictor - Reliable deep learning tool for in vivo lifespan prediction

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

AI-based Method and Tool (DeepNeo) for Intravascular Optical Coherence Tomography Image Analysis of Coronary Artery Neointimal Tissue

Novel TPH inhibitors for the treatment of fibrotic diseases and pulmonary arterial hypertension (PAH)

Novel diagnostic for Peripartum cardiomyopathy (PPCM) in pregnant women

Bioartificial vascular grafts based on a highly compacted acellular fibrin matrix

Automated production of cardiac organoids

Non-invasive pressure gradient prediction for a cardiovascular narrowing

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

Consolidated Bioprocessing of Complex Carbohydrates to D-Erythro-Isocitric Acid Using a Fungus

Non-invasive and high-throughput monitoring of exon-specific isoform expression

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

A FRET-based method to measure seeding activity of misfolded protein species in complex biological samples

Self-Organizing Human 2D Neuromuscular Junction Model and 3D Neuromuscular Organoids

Dream Complex Inhibitors for Treating Medical Conditions Induced by Circadian Rhythm Disruption

Spider silk/fibrin implant for the regeneration of injured spinal cord

Novel CARs for the Treatment of Multiple Sclerosis and Alzheimer´s Disease

Microelectrode array with combined optical stimulation

Ferulic acid derivatives as efficient neuroprotective agent and memory enhancer

Novel Therapy for Treatment of Alzheimer´s Disease

microRNA Signature Indicates Risk for Cognitive Decline

Vinpocetine inhibiting PDE1, a target for disease modifying therapy of synucleinopathies like multiple system atrophy (MSA)

Treating dementia and other brain disorders with natural glycans

NMDAR targeted CAAR-T cell therapy

HERV inhibitors for use in tauopathies

HSV signature antibodies predict the development of anti-NMDA receptor encephalitis

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

Rapid quantitation of virus-neutralizing antibodies in biosamples - a novel BSL1 approach based on virus-like particles (VLPs)

Cystobactamids – novel antibacterials against gram-negative pathogens

Phytosphingosine Derivatives as Adjuvants in Immune Stimulation

Identifying Cellular States and Fate Transitions via Synthetic Locus Control Regions (sLCRs)

Efficient, adjuvant-free mucosal vaccination via IgA feedback loop

SARSeq: Multiplexed, parallel detection of SARS-CoV2 variants and other viruses in high-throughput

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

Particle-mediated transport of dissolved active agents into hair follicles

Tyrolian algae extract with anti-inflammatory potential

Rapid quantitation of virus-neutralizing antibodies in biosamples - a novel BSL1 approach based on virus-like particles (VLPs)

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

Innovative DOTA-Linkers for Bacterial Targeting

Increased Availability and Efficacy of Aminoglycosides

CRISPRdetect – multiplexed RNA detection with reprogrammed tracrRNAs

Novel Lectin-Targeting therapeutics and diagnostics for Pseudomonas aeruginosa infections

Rapid Detection of Shiga toxin producing E.coli (STEC) 

Programmable RNA-Guided Enzymes and Novel Orthogonal Substrates for Crispr Diagnostics

Method and kit for early detection of preeclampsia

Autofocus-control of a microscope including an electrically tunable lens

3D-Seq: Localizing Spatial Gene Expression in 3-Dimensions on Single Cell-Level

FLAM-Seq: Genome-wide full-length mRNA and poly(A)-tail sequencing

A FRET-based method to measure seeding activity of misfolded protein species in complex biological samples

Diagnostic assay for determination of personal microbial metabolite production profile for nutritional adjustment

Cytotoxicity Assay for detecting Cellular Damage

Functionalized Nanoparticles for Viral Clearance

Blood-based tuberculosis precision medicine: transcriptomic model shortens therapy duration

Epigenetic detection of early-stage non-small cell lung cancer in blood

Flow cytometric basophil activation test for automated, high-throughput allergy diagnostics

Blood-based tuberculosis precision medicine: transcriptomic model predicts treatment response

Replacement of allergen challenge: Safely scoring prevalence & severity of allergies

LncRNA LIPCAR predicts disease progression in heart failure and myocardial infarction patients

Novel diagnostic for Peripartum cardiomyopathy (PPCM) in pregnant women

Predicting the therapeutic effect of compositions containing BH3 mimetics

Time-efficient assessment of pulmonary function via CT with low radiation doses

Novel Diagnostic Marker For Early Detection Of Bladder Cancer

Biomarker Panel for Diagnosing Pulmonary Dysfunction

microRNA Signature Indicates Risk for Cognitive Decline

Non-invasive measurement of myocardial power

Non-invasive pressure gradient prediction for a cardiovascular narrowing

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

HSV signature antibodies predict the development of anti-NMDA receptor encephalitis

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

The Prognostic Umbilical Swab: A Rapid Molecular Risk Stratification Tool for Neonatal Sepsis and Brain Injury

Liver Function imaging of the functional hepatic reserve

FAP-targeted dual imaging for guided cancer surgery

SARSeq: Multiplexed, parallel detection of SARS-CoV2 variants and other viruses in high-throughput

Efficient multiplex cryo-embedding method for cost-efficient, high-throughput tissue analysis

Biomarker set for early and non-invasive diagnosis and differentiation of renal cell carcinomas

Innovative DOTA-Linkers for Bacterial Targeting

Increased Availability and Efficacy of Aminoglycosides

Biodynamers enhance drug delivery

Overcoming resistance - Innovative broad-spectrum inhibitors of Metallo- β-lactamases

Particle-mediated transport of dissolved active agents into hair follicles

Novel therapy approach for treatment of lung fibrosis

Novel TPH inhibitors for the treatment of fibrotic diseases and pulmonary arterial hypertension (PAH)

Nutritional compositions for treating dysfunction of liver fat metabolism – VAFD

Liver stem cell generation for therapeutic applications

The ASGPR-CAR – a liver-specific chimeric antigen receptor

Novel CARs for the Treatment of Inflammatory Bowel Disease

Broadly neutralizing antibodies against hepatitis E virus (HEV)

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

Liver Function imaging of the functional hepatic reserve

Novel therapy approach for treatment of lung fibrosis

WarpDemuX - Method for Demultiplexing of RNA-sequencing DATA

CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction

Human TCR constructs for adoptive cell therapy of cancer

Liver stem cell generation for therapeutic applications

AAV Vector Variants for Ocular Gene Delivery

Next generation allogeneic CAR-NK cell platform for treatment of malignant diseases

Reprogramming immune cells for CAR cell-based therapies

Immunosuppressant resistance in anti-viral T cell products 

High-level recombinant adeno-associated virus production

The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer

Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out

Gene editing of the proteinase 3 autoantigen as a novel treatment for ANCA-associated vasculitis

An engineered serine integrase for targeted gene transfer in human cells

BreakTag - Novel method for detection of ds-breaks and analysis of CRISPR-induced on- and off-target effects

Non-invasive and high-throughput monitoring of exon-specific isoform expression

Expansion of pancreatic progenitors derived from human pluripotent stem cells und GMP-compliant conditions

Biodynamers enhance drug delivery

Stable Gene Transfer with Hyperactive Sleeping Beauty Transposase SB100X

Improved Sleeping Beauty Transposon System for gene therapy: SB100X/pT4

CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction

Homology Independent Genomic Sequence Replacement

Spacer-nick genome editing of hematopoietic stem and progenitor cells and T cells

Sleeping Beauty transposase variants with increased safety due to reduced half-life

Safer Sleeping Beauty transposase variants with improved integration profiles 

Activity-enhanced variant of hyperactive Sleeping Beauty transposase SB100X

AAV Vector Variants for Ocular Gene Delivery

Non-integrating alpharetrovirus-based vector particles for efficient RNA delivery and targeted gene modification

Maintenance of regulatory T cell phenotype by expression of IL-2 fusion protein

Reprogramming immune cells for CAR cell-based therapies

Immunosuppressant resistance in anti-viral T cell products 

High-level recombinant adeno-associated virus production

CD3-CAR NK-92 cell-mediated TCR+ depletion

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer

Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out

An engineered serine integrase for targeted gene transfer in human cells

BreakTag - Novel method for detection of ds-breaks and analysis of CRISPR-induced on- and off-target effects

CRISPR Switch: Inducible sgRNA expression for tightly regulated, efficient and safer CRISPR/Cas9 genome editing

CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models

Consolidated Bioprocessing of Complex Carbohydrates to D-Erythro-Isocitric Acid Using a Fungus

Keanumycins – Antifungal and Amoebicidal Natural Compounds for Agricultural Biocontrol

Triggering of plant immunity through bacterial hydroxy fatty acid metabolites

Green Rodenticide - Use of a Grayanotoxin-Based Agent for Rodent Control

INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

Phytosphingosine Derivatives as Adjuvants in Immune Stimulation

Plasma cell-specific antibodies targeting BCMA for the treatment of multiple myeloma and autoimmune diseases

Spacer-nick genome editing of hematopoietic stem and progenitor cells and T cells

Sleeping Beauty transposase variants with increased safety due to reduced half-life

Functionalized Nanoparticles for Viral Clearance

Flow cytometric basophil activation test for automated, high-throughput allergy diagnostics

Replacement of allergen challenge: Safely scoring prevalence & severity of allergies

The physiological breast-milk proteins S100A8 and S100A9 promote an eubiotic gut state in infants

Novel treatment for sepsis in newborns

Genetically Manipulated Cornea for Transplantation

Engineered Immune Cells to Specifically Eliminate Undesired Immune Responses

Maintenance of regulatory T cell phenotype by expression of IL-2 fusion protein

The ASGPR-CAR – a liver-specific chimeric antigen receptor

Novel CARs for the Treatment of Multiple Sclerosis and Alzheimer´s Disease

Novel CARs for the Treatment of Inflammatory Bowel Disease

NMDAR targeted CAAR-T cell therapy

Immunosuppressant resistance in anti-viral T cell products 

CD3-CAR NK-92 cell-mediated TCR+ depletion

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

HSV signature antibodies predict the development of anti-NMDA receptor encephalitis

Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out

Gene editing of the proteinase 3 autoantigen as a novel treatment for ANCA-associated vasculitis

An engineered serine integrase for targeted gene transfer in human cells

Method for direct measurement of functional avidity of T cells

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models

Rapid quantitation of virus-neutralizing antibodies in biosamples - a novel BSL1 approach based on virus-like particles (VLPs)

Novel Myxopyronin Analogues and Myxopyronin Genecluster for Mutasynthesis

Cystobactamids – novel antibacterials against gram-negative pathogens

Innovative DOTA-Linkers for Bacterial Targeting

Novel Labyrinthopeptins as anti-viral agents

Increased Availability and Efficacy of Aminoglycosides

Highly active Chlorotonil A Derivatives for the treatment of Malaria

Oral Antimotilin-Based Inhibitors for Treating Helicobacter pylori Infections

First-in-Class S. aureus α-Hemolysin Inhibitors for Lung and Skin Infections 

Phytosphingosine Derivatives as Adjuvants in Immune Stimulation

CRISPRdetect – multiplexed RNA detection with reprogrammed tracrRNAs

Overcoming resistance - Innovative broad-spectrum inhibitors of Metallo- β-lactamases

Best-In-Class P. aeruginosa LasB virulence factor Inhibitors

Best-in-class Darobactin derivate against Gram-negative Bacteria

Novel Lectin-Targeting therapeutics and diagnostics for Pseudomonas aeruginosa infections

Novel vaccine vector platform for safe and effective immunization using a replication-deficient murine cytomegalovirus (MCMV)

Novel inhibitors of Cytomegalovirus

Inhibitors of Energy Coupling Factor (ECF) Transporters Against Gram-Positive Pathogens

Rapid Detection of Shiga toxin producing E.coli (STEC) 

DeColi: Gut Decolonization of Multi-Resistant Escherichia coli

Novel ASO-Based mRNA Silencing Technology for Phage-Host Interaction Research

Jagaricin – a novel antifungal natural compound

Functionalized Nanoparticles for Viral Clearance

Targeting host lipid homeostasis to augment anti-mycobacterial treatment

Blood-based tuberculosis precision medicine: transcriptomic model shortens therapy duration

Blood-based tuberculosis precision medicine: transcriptomic model predicts treatment response

Efficient, adjuvant-free mucosal vaccination via IgA feedback loop

Novel treatment for sepsis in newborns

Broadly neutralizing antibodies against hepatitis E virus (HEV)

Immunosuppressant resistance in anti-viral T cell products 

Broad-spectrum antiviral compounds against known and emerging viruses

HSV signature antibodies predict the development of anti-NMDA receptor encephalitis

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

The Prognostic Umbilical Swab: A Rapid Molecular Risk Stratification Tool for Neonatal Sepsis and Brain Injury

SARSeq: Multiplexed, parallel detection of SARS-CoV2 variants and other viruses in high-throughput

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

Keratinophile photosensitizers for safe and rapid treatment of onychomycosis

Autofocus-control of a microscope including an electrically tunable lens

Bioartificial vascular grafts based on a highly compacted acellular fibrin matrix

Irradiation device and method for optical cochlear implants and laser surgery sytems

Time-efficient assessment of pulmonary function via CT with low radiation doses

Effective prevention of biofilm-associated infections on dental implants

Spider silk/fibrin implant for the regeneration of injured spinal cord

Microelectrode array with combined optical stimulation

“Multiplextrode” – a completely novel electrode for analogue multiplexing

Method and arrangement for identification and correction of optical aberrations

Non-invasive measurement of myocardial power

Non-invasive pressure gradient prediction for a cardiovascular narrowing

Reprogramming immune cells for CAR cell-based therapies

Fiber Membrane Oxygenator with Minimized Priming Volume

Novel gas flow system for high throughput determination of oxygen dissociation curves (ODC)

Ultra-thin imaging fiber endoscope using a diffuser as encoder and a deep neural network as decoder

Expansion of pancreatic progenitors derived from human pluripotent stem cells und GMP-compliant conditions

Novel TPH inhibitors for the treatment of fibrotic diseases and pulmonary arterial hypertension (PAH)

UV-Fit – increasing metabolic fitness and reducing body weight without fasting

Nutritional compositions for treating dysfunction of liver fat metabolism – VAFD

Dream Complex Inhibitors for Treating Medical Conditions Induced by Circadian Rhythm Disruption

A scalable and highly sensitive assay for measuring extracellular NAD+ level in human body fluids

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

Non-invasive and high-throughput monitoring of exon-specific isoform expression

INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

Drug combinations to overcome therapy resistance in cancer

Plasma cell-specific antibodies targeting BCMA for the treatment of multiple myeloma and autoimmune diseases

Improved Sleeping Beauty Transposon System for gene therapy: SB100X/pT4

Selective Inhibitors of Genotoxic Stress Induced IKK/NFκB Pathways for Cancer Therapy

Sleeping Beauty transposase variants with increased safety due to reduced half-life

Human TCR constructs for adoptive cell therapy of cancer

Epigenetic detection of early-stage non-small cell lung cancer in blood

Efficient, adjuvant-free mucosal vaccination via IgA feedback loop

Predicting the therapeutic effect of compositions containing BH3 mimetics

LS-COAT – an exceptionally efficient tumor vaccination approach

Novel Diagnostic Marker For Early Detection Of Bladder Cancer

Prediction of L-Asparaginase resistance in tumor therapy

T-cell therapy of MYD88L265P-dependent B-cell lymphoma

Next generation allogeneic CAR-NK cell platform for treatment of malignant diseases

A novel immuno-oncology approach for induction and massive amplification of antigen-specific cytotoxic CD8⁺ T-cells

CD3-CAR NK-92 cell-mediated TCR+ depletion

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

NICHE-CAR-T: NR2F6 Immune Checkpoint Harnessing to Enhance CAR-T efficacy

FAP-targeted dual imaging for guided cancer surgery

CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models

SARSeq: Multiplexed, parallel detection of SARS-CoV2 variants and other viruses in high-throughput

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

Efficient multiplex cryo-embedding method for cost-efficient, high-throughput tissue analysis

Biomarker set for early and non-invasive diagnosis and differentiation of renal cell carcinomas

Efficient Generation of Murine Brain Organoids from Adult Neural Stem Cells

Improved Sleeping Beauty Transposon System for gene therapy: SB100X/pT4

Spacer-nick genome editing of hematopoietic stem and progenitor cells and T cells

Self-Organizing Human 2D Neuromuscular Junction Model and 3D Neuromuscular Organoids

UV-Fit – increasing metabolic fitness and reducing body weight without fasting

Lifespan predictor - Reliable deep learning tool for in vivo lifespan prediction

Nutritional compositions for treating dysfunction of liver fat metabolism – VAFD

Dream Complex Inhibitors for Treating Medical Conditions Induced by Circadian Rhythm Disruption

LS-COAT – an exceptionally efficient tumor vaccination approach

Method for high-yield production of megakaryocytes

Time-efficient assessment of pulmonary function via CT with low radiation doses

Method and arrangement for identification and correction of optical aberrations

Reprogramming immune cells for CAR cell-based therapies

Tyrolian algae extract with anti-inflammatory potential

Non-invasive and high-throughput monitoring of exon-specific isoform expression

INSPECT - Intron encoded reporter transcripts for minimally invasive monitoring of coding and non-coding RNAs

Ex vivo method for determination of oxidative stress and diagnosis of ferroptosis-associated diseases

AI-based Method and Tool (DeepNeo) for Intravascular Optical Coherence Tomography Image Analysis of Coronary Artery Neointimal Tissue

Biodynamers enhance drug delivery

Prediction for targeting efficiency of guide RNA for a gene of interest in bacteria

Metax: Cross-Domain Metagenomic Profiling Technology

Stable Gene Transfer with Hyperactive Sleeping Beauty Transposase SB100X

Short Term Isotope Pulse Labeling Method for Analyzing Metabolic States and Drug Targets in Biological Samples

Genome Architecture Mapping (GAM)

Improved Sleeping Beauty Transposon System for gene therapy: SB100X/pT4

CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction

Homology Independent Genomic Sequence Replacement

Autofocus-control of a microscope including an electrically tunable lens

Identifying Cellular States and Fate Transitions via Synthetic Locus Control Regions (sLCRs)

3D-Seq: Localizing Spatial Gene Expression in 3-Dimensions on Single Cell-Level

FLAM-Seq: Genome-wide full-length mRNA and poly(A)-tail sequencing

A FRET-based method to measure seeding activity of misfolded protein species in complex biological samples

Self-Organizing Human 2D Neuromuscular Junction Model and 3D Neuromuscular Organoids

Advancing Bioproduction: HDLBP overexpression enhances protein production and secretion

Sleeping Beauty transposase variants with increased safety due to reduced half-life

Lifespan predictor - Reliable deep learning tool for in vivo lifespan prediction

ProteasomeID - Quantitative mapping of proteasome interactomes and substrates in vitro and in vivo

Flow cytometric basophil activation test for automated, high-throughput allergy diagnostics

Automated production of cardiac organoids

Wireless Miniature Microscope For Near-Field Image-Capturing

Method and arrangement for identification and correction of optical aberrations

A scalable and highly sensitive assay for measuring extracellular NAD+ level in human body fluids

High-level recombinant adeno-associated virus production

Method for tuning brain network models for the implementation of brain digital twins

CD3-CAR NK-92 cell-mediated TCR+ depletion

Method for Assessing Out-of-Specification (OOS) CAR T-Cell Products and Predicting Patient Response

Advanced tracer compounds for enhanced detection of cellular structures

Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out

An engineered serine integrase for targeted gene transfer in human cells

Rapid, simultaneous and non-destructive blood diagnostics using a multi-omics NMR platform

BreakTag - Novel method for detection of ds-breaks and analysis of CRISPR-induced on- and off-target effects

CRISPR Switch: Inducible sgRNA expression for tightly regulated, efficient and safer CRISPR/Cas9 genome editing

CRISPR StAR: facilitating high resolution genetic screening in complex in vivo models

Two-Dimensional Redundant Dual Barcoding for Ultra-High-Throughput, Error-Resilient Nucleic Acid Analysis

SCON – Artificial intron devoid of hypomorphic target gene effects for one-step generation of conditional animal models

Efficient multiplex cryo-embedding method for cost-efficient, high-throughput tissue analysis

AI-based Method and Tool (DeepNeo) for Intravascular Optical Coherence Tomography Image Analysis of Coronary Artery Neointimal Tissue

Prediction for targeting efficiency of guide RNA for a gene of interest in bacteria

WarpDemuX - Method for Demultiplexing of RNA-sequencing DATA

Drug Dosage Optimization Based on Machine Learning and Mechanistic Modeling

CrispRGold - Design of efficient CrispR/Cas sgRNA sequences and off-target prediction

Lifespan predictor - Reliable deep learning tool for in vivo lifespan prediction

Time-efficient assessment of pulmonary function via CT with low radiation doses

Non-invasive measurement of myocardial power

Non-invasive pressure gradient prediction for a cardiovascular narrowing

Method for tuning brain network models for the implementation of brain digital twins

Short Term Isotope Pulse Labeling Method for Analyzing Metabolic States and Drug Targets in Biological Samples

Autofocus-control of a microscope including an electrically tunable lens

Irradiation device and method for optical cochlear implants and laser surgery sytems

Microelectrode array with combined optical stimulation

Wireless Miniature Microscope For Near-Field Image-Capturing

“Multiplextrode” – a completely novel electrode for analogue multiplexing

Method and arrangement for identification and correction of optical aberrations

Fiber Membrane Oxygenator with Minimized Priming Volume

Injection tunnel for stress-reduced handling of laboratory mice

Efficient multiplex cryo-embedding method for cost-efficient, high-throughput tissue analysis

Novel therapy approach for treatment of lung fibrosis

Drug combinations to overcome therapy resistance in cancer

Expansion of pancreatic progenitors derived from human pluripotent stem cells und GMP-compliant conditions

Cystobactamids – novel antibacterials against gram-negative pathogens

Novel Labyrinthopeptins as anti-viral agents

Increased Availability and Efficacy of Aminoglycosides

Highly active Chlorotonil A Derivatives for the treatment of Malaria

Biodynamers enhance drug delivery

Oral Antimotilin-Based Inhibitors for Treating Helicobacter pylori Infections

First-in-Class S. aureus α-Hemolysin Inhibitors for Lung and Skin Infections 

Overcoming resistance - Innovative broad-spectrum inhibitors of Metallo- β-lactamases

Best-In-Class P. aeruginosa LasB virulence factor Inhibitors

Next-Generation Probiotics

Best-in-class Darobactin derivate against Gram-negative Bacteria

Novel Lectin-Targeting therapeutics and diagnostics for Pseudomonas aeruginosa infections

Novel vaccine vector platform for safe and effective immunization using a replication-deficient murine cytomegalovirus (MCMV)

Novel inhibitors of Cytomegalovirus

Inhibitors of Energy Coupling Factor (ECF) Transporters Against Gram-Positive Pathogens

Thiourea-Based Antibiotics against Acinetobacter baumannii

DeColi: Gut Decolonization of Multi-Resistant Escherichia coli

Novel ASO-Based mRNA Silencing Technology for Phage-Host Interaction Research

Stable Gene Transfer with Hyperactive Sleeping Beauty Transposase SB100X

Novel TPH inhibitors for the treatment of fibrotic diseases and pulmonary arterial hypertension (PAH)

Plasma cell-specific antibodies targeting BCMA for the treatment of multiple myeloma and autoimmune diseases

Improved Sleeping Beauty Transposon System for gene therapy: SB100X/pT4

Selective Inhibitors of Genotoxic Stress Induced IKK/NFκB Pathways for Cancer Therapy

Spacer-nick genome editing of hematopoietic stem and progenitor cells and T cells

Human TCR constructs for adoptive cell therapy of cancer

Jagaricin – a novel antifungal natural compound

Functionalized Nanoparticles for Viral Clearance

Nutritional compositions for treating dysfunction of liver fat metabolism – VAFD

Dream Complex Inhibitors for Treating Medical Conditions Induced by Circadian Rhythm Disruption

Liver stem cell generation for therapeutic applications

The physiological breast-milk proteins S100A8 and S100A9 promote an eubiotic gut state in infants

Novel treatment for sepsis in newborns

LS-COAT – an exceptionally efficient tumor vaccination approach

Engineered Immune Cells to Specifically Eliminate Undesired Immune Responses

AAV Vector Variants for Ocular Gene Delivery

Novel Treatment of Pulmonary Arterial Hypertension (PAH)

HLA-DR-specific γδ T-cell receptor to treat proliferative disorders of HLA-DR+ cells

Microelectrode array with combined optical stimulation

Ferulic acid derivatives as efficient neuroprotective agent and memory enhancer

Novel Therapy for Treatment of Alzheimer´s Disease

microRNA Signature Indicates Risk for Cognitive Decline

Treating dementia and other brain disorders with natural glycans

NMDAR targeted CAAR-T cell therapy

HERV inhibitors for use in tauopathies

T-cell therapy of MYD88L265P-dependent B-cell lymphoma

Next generation allogeneic CAR-NK cell platform for treatment of malignant diseases

Reprogramming immune cells for CAR cell-based therapies

Immunosuppressant resistance in anti-viral T cell products 

A novel immuno-oncology approach for induction and massive amplification of antigen-specific cytotoxic CD8⁺ T-cells

High-level recombinant adeno-associated virus production

The CXCR3alt-CXCL11 chemokine system for therapeutic use in solid cancer

Base editing enzymes for multiplex editing with simultaneous gene knock-in and knock-out

Method for direct measurement of functional avidity of T cells

Tyrolian algae extract with anti-inflammatory potential

NICHE-CAR-T: NR2F6 Immune Checkpoint Harnessing to Enhance CAR-T efficacy

Keratinophile photosensitizers for safe and rapid treatment of onychomycosis

Cyclic di-Nucleotides as adjuvants

Cyclic-di-AMP: a promising adjuvant for neonatal vaccines

Biodynamers enhance drug delivery

Phytosphingosine Derivatives as Adjuvants in Immune Stimulation

Novel vaccine vector platform for safe and effective immunization using a replication-deficient murine cytomegalovirus (MCMV)

Efficient, adjuvant-free mucosal vaccination via IgA feedback loop

LS-COAT – an exceptionally efficient tumor vaccination approach

VSV-encoded HCV vaccines that induce broadly neutralising antibodies against Hepatitis C

A novel immuno-oncology approach for induction and massive amplification of antigen-specific cytotoxic CD8⁺ T-cells